Bibliometrics and Visualization Analysis of Podophyllotoxin Literature Based on Web of Science Database
- VernacularTitle:基于Web of Science数据库的鬼臼毒素文献计量学及可视化分析
- Author:
Yuanhui GUO
1
;
Baixuan SHEN
;
Jialin WANG
;
Wanying WANG
;
Jiajia DUAN
;
Chuanxin LIU
Author Information
- Publication Type:Journal Article
- Keywords: Podophyllotoxin; Dysosma versipellis; Bibliometrics; Visualization analysis; Anti-tumor; Toxic mechanism
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2025;27(2):508-521
- CountryChina
- Language:Chinese
- Abstract: Objective To provide reference for future basic research and clinical research,the research status and trend of podophyllotoxin were explored.Methods Based on Citespace and R software,the co-occurrence map,keyword clustering and burst analysis of the English literature on podophyllotoxin in the Scientific Core Collection(WoSCC)were carried out to explore the research hotspots and analyze the frontier progress.Results A total of 1220 papers on podophyllotoxin published by 531 institutions from 77 countries and regions were retrieved.The number of published papers showed an overall upward trend.The analysis of the author 's cooperation network map showed that there was cooperation and communication between the authors,but it was relatively scattered,and the cooperation was not close.This phenomenon also existed in the relationship between research institutions.The country with the largest number of papers was China,and the institution was Lanzhou University.869 authors participated in the research in this field,and 422 academic journals published papers on podophyllotoxin.Among them,podophyllotoxin,derivatives,analogues,biological evaluation and etoposide had a high frequency of occurrence,indicating that these fields had high attention and great research potential.Conclusion In recent years,the research on podophyllotoxin and its derivatives in the treatment of tumors has developed rapidly.In addition,the pharmacological effects and gene regulation of podophyllotoxin are also new research trends.The research hotspots show a trend of diversification,which provides strong evidence for further exploring the molecular mechanism of podophyllotoxin in the treatment of various diseases.However,the lack of relatively in-depth basic research has limited the development of clinical research.
