Application Progress of Lipidomics in Diabetic Nephropathy
- VernacularTitle:脂质组学在糖尿病肾病研究中的应用进展
- Author:
Zhengwei DONG
1
;
Kang YANG
;
Yubo LI
;
Huan ZHAO
Author Information
- Publication Type:Journal Article
- Keywords: Diabetic nephropathy; Diabetes mellitus; Lipidomics; Biomarkers; Application progresss
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2025;27(2):321-328
- CountryChina
- Language:Chinese
- Abstract: Diabetic nephropathy(DN)is a chronic complication that leads to the high mortality of diabetes mellitus(DM)patients.Many researchers are devoted to the diagnosis,etiology,process and molecular mechanism of treatment of DN.At present,the regulation of small molecular lipids on renal function and the role in the pathogenesis of DN are gradually becoming clear,and lipidomics has also become a powerful tool in DN research.DN is characterised by disorders of lipid metabolism,and lipidomics plays an important role in the characterisation of lipid metabolic profiles,diagnosis,mechanistic investigation and treatment of DN because of its unique relevance.But at the same time,the lipids in the body are complex,which brings great challenges to the detection and analysis of lipids.In the future,multidisciplinary crossover and multi-omics association is the direction of lipidomics breakthrough.This article outlines the progress of the application of lipidomics in DN research strategies,lipid metabolic profiling,early diagnosis,drug efficacy and mechanism exploration,and histological co-analysis,and further discusses the opportunities and challenges of the future application of lipidomics in DN,with the aim of providing a clear picture of the current status of the research and the prospects for researchers in the relevant directions.
