Multi-center Study on Specific IgE Antibodies to Alternaria Alternata and Aspergillus Fumigatus in Sera of Clinical Allergy Patients in Selected Provinces in China
10.3969/j.issn.1671-7414.2025.03.003
- VernacularTitle:中国部分省市临床过敏患者血清链格孢霉和烟曲霉特异性IgE抗体检测的多中心调查研究
- Author:
Chao XU
1
;
Xingyuan ZHU
;
Caizhi HUANG
;
Hong ZHU
;
Shu WANG
;
Hongxia YUAN
;
Pengfei ZHAO
;
Ji YAN
;
Jianhua MA
;
Chunlei KUANG
;
Yanli XIE
;
Rongcai WU
;
Yu ZHANG
;
Sheng LIANG
;
Qunying WANG
;
Yingsha DUAN
;
Yiwu ZHENG
Author Information
1. 大连妇女儿童医疗中心(集团)呼吸实验室,辽宁 大连 116000
- Publication Type:Journal Article
- Keywords:
Alternaria alternate;
Aspergillus fumigatus;
IgE
- From:
Journal of Modern Laboratory Medicine
2025;40(3):13-17
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the prevalence of specific IgE antibodies against Alternaria alternata and Aspergillus fumigatus in serum samples from clinical allergy patients across selected provinces in China.Methods Data on specific IgE antibodies for Alternaria A.and Aspergillus F.were collected from 20 hospital laboratories in 17 cities spanning 11 provinces.The study analyzed the levels of specific IgE and their variations across different provinces and seasons.Results A total of 27 471 cases of Alternaria A.and 32 843 cases of Aspergillus F.specific IgE data were included.The national average positive rate of Alternaria A.IgE was 10.40%,with the highest rate of 22.68%in Jiangsu and the lowest rate of 2.06%in Guangxi.For Aspergillus F.specific IgE,the average positive rate was 4.24%,with Hubei province having the highest rate(7.25%)and Hunan province the lowest(1.23%).The difference in IgE levels for both Alternaria A.and Aspergillus F.among provinces were statistically significant(H=9 955,16 993,all P<0.0001).Among patients,5.85%had Alternaria A.specific IgE levels at grade 3 or above,while only 0.57%had Aspergillus F.specific IgE levels at this level.When examining seasonal variations using data from Liaoning,Hunan and Anhui provinces,significant seasonal changes were observed for both Alternaria A.and Aspergillus F.IgE antibodies(HAlternaria A=347.6,338.0,401.3,HAspergillus F=196.6,133.7,231.7,all P<0.0001).Conclusion The sensitization to Alternaria A.and Aspergillus F.exhibits distinct geographical characteristics and vary significantly with seasons.Given the relatively high IgE levels associated with Alternaria A.,it should be given adequate clinical attention.
