Endogenous bioactive small molecules and vascular calcification
10.20039/j.cnki.1007-3949.2025.01.001
- VernacularTitle:内源性生物活性小分子与血管钙化
- Author:
Rui WANG
1
;
Sanbao CHAI
;
Yongfen QI
Author Information
1. 北京大学基础医学院心血管生物活性分子实验室;北京大学血管稳态与重构国家重点实验室;北京大学医学部基础医学院病原生物学系,北京市 100083
- Publication Type:Journal Article
- Keywords:
vascular calcification;
endogenous bioactive small molecule;
cardiovascular bioactive peptide;
adipokine;
gaseous molecule
- From:
Chinese Journal of Arteriosclerosis
2025;33(1):1-8
- CountryChina
- Language:Chinese
-
Abstract:
Endogenous bioactive small molecules are characterized by low molecular weight,high biological activity,low immunogenicity,and rapid synthesis and metabolism,play a pivotal role in maintaining vascular homeostasis.Vascular calcification(VC)is a abnormal deposition of calcium and phosphorus in the vessel wall.Endogenous bioactive small molecules such as cardiovascular bioactive peptides,adipokines and gaseous molecules participate in the process of VC through various mechanisms.This review summarises the advances in relationship between endogenous bioactive small molecules and the occurrence,development,and related mechanisms of VC.
