Association between carotid perivascular adipose tissue and intraplaque hemorrhage on carotid CT angiography
10.3760/cma.j.cn112149-20240325-00155
- VernacularTitle:颈动脉CT血管成像斑块周围脂肪组织与斑块内出血的相关性研究
- Author:
Shuai ZHANG
1
;
Sha LI
1
;
Tianqi XU
1
;
Ximing WANG
1
Author Information
1. 山东第一医科大学附属省立医院影像科，济南 250000
- Publication Type:Journal Article
- Keywords:
Atherosclerosis;
Carotid artery;
Perivascular adipose tissue;
Intraplaque hemorrhage;
Computed tomography angiography
- From:
Chinese Journal of Radiology
2025;59(2):199-205
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the relationship between carotid intraplaque hemorrhage (IPH) in CT angiography(CTA) and perivascular fat density (PFD).Methods:This study retrospectively analyzed 103 patients with carotid atherosclerosis, including 209 carotid plaques, who received carotid CTA and high-resolution magnetic resonance angiography in Shandong Provincial Hospital Affiliated to Shandong First Medical University from January 2018 to July 2023. According to the evaluation of IPH by MRI, the plaques were divided into IPH group ( n=85) and non IPH group ( n=124). CTA was used to evaluate the plaque characteristics (calcification, lumen stenosis, maximum plaque thickness and plaque density) and PFD. Univariate and multivariate logistic analysis was used to evaluate the relationship between PFD and IPH. The diagnostic efficacy of multiple features was performed by receiver operating characteristic curve analysis. Results:Finally, 103 patients with 209 carotid plaques were collected. Multivariate logistic regression analysis showed that PFD ( OR=1.183, 95% CI 1.104-1.267, P<0.001) still showed a significant association with IPH after adjusting for age, hyperlipidemia, degree of luminal stenosis, plaque calcification, maximum plaque thickness, and plaque density. The area under the curve values, sensitivity, specificity, and accuracy of combined PFD, maximum plaque thickness, and plaque density were 0.980, 88.24%, 98.39%, and 94.26%, respectively. Conclusion:The changes of PFD in the carotid artery are closely related to the presence of carotid IPH in MRI and may become a new imaging indicator for high-risk plaque identification and cerebrovascular risk assessment.
