Cardiovascular magnetic resonance-based measurement of ventricular structure, function, and associated factors in healthy Tibetan volunteers at ultra-high altitudes
10.3760/cma.j.cn112149-20250311-00124
- VernacularTitle:基于心血管MR的超高海拔地区藏族健康志愿者心室结构和功能评估及其相关因素研究
- Author:
Zhijie ZHANG
1
;
Yining WANG
;
Yonggang CUI
;
Yue SUN
;
Yanming LEI
;
Cidan WANGJIU
;
Yan ZENG
;
Ruiting BAI
;
Jian CAO
Author Information
1. 西藏自治区人民医院放射科，拉萨 850000
- Publication Type:Journal Article
- Keywords:
Magnetic resonance imaging;
Altitude;
Ventricular function;
Reference values;
Sex factors
- From:
Chinese Journal of Radiology
2025;59(5):526-531
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish reference ranges for left and right ventricular structure and function parameters using cardiovascular magnetic resonance (CMR) in healthy Tibetan natives residing at ultra-high altitudes, and analyze their influencing factors.Methods:This prospective study enrolled Tibetan healthy volunteers who underwent CMR examinations between September 2021 and August 2022. Participants were stratified into four age groups: 20-29, 30-39, 40-49, and 50-59 years. CMR-derived parameters included left ventricular ejection fraction (LVEF), right ventricular ejection fraction (RVEF), left/right ventricular end-diastolic volumes (LVEDV/RVEDV), left/right ventricular end-systolic volumes (LVESV/RVESV), and end-diastolic left ventricular mass (LVM at ED). Normally distributed data were compared between genders using independent samples t-test and among age groups using ANOVA. Non-normally distributed data were analyzed with Kruskal-Wallis test. Linear regression assessed relationships between parameters and gender, age, residential altitude, body surface area (BSA), and body mass index (BMI). Results:The study included 66 volunteers (27 males, 39 females), distributed as follows: 21 (20-29 years), 15 (30-39 years), 15 (40-49 years), and 15 (50-59 years). Reference values were: LVEF (62.6±5.7)%, RVEF (55.0±7.1)%, BSA-indexed LVEDV (60.6±12.1)ml/m2, RVEDV (65.5±14.8)ml/m2, LVESV (22.7±5.9)ml/m2, RVESV (29.6±8.1)ml/m2, and LVM at ED (39.1±8.0)g/m2. Gender and age significantly affected RVEF, RVESV, and LVM at ED ( P<0.05). Multivariate regression revealed:Gender independently predicted RVEF ( β=-5.556, P=0.003), RVESV ( β=5.421, P=0.007), and LVM at ED ( β=8.338, P<0.001). Age negatively influenced RVESV ( β=-0.202, P=0.019). BSA positively correlated with LVM at ED ( β=19.980, P=0.041). No significant associations were found with residential altitude or BMI ( P>0.05). Conclusion:This study establishes preliminary reference ranges for ventricular parameters in Tibetan ultra-high altitude natives, with gender, age, and BSA identified as key determinants of cardiac structural/functional indices.
