Diagnostic Value of Serum miR-322 and miR-568 Levels Combined with Electrocardiogram Parameters in Patients with Chronic Heart Failure Complicated with Ventricular Arrhythmias
10.3969/j.issn.1671-7414.2025.03.022
- VernacularTitle:血清miR-322,miR-568水平检测与心电图参数联合对慢性心力衰竭患者并发室性心律失常的诊断价值
- Author:
Lijuan LI
1
;
Xian LI
;
Xiangjun JI
;
Guili WANG
;
Liyan CHANG
;
Yanli ZHONG
;
Jianfen LIN
Author Information
1. 张家口市第一医院电生理科,河北 张家口 075000
- Publication Type:Journal Article
- Keywords:
electrocardiogram parameters;
miR-322;
miR-568;
chronic heart failure;
ventricular arrhythmias
- From:
Journal of Modern Laboratory Medicine
2025;40(3):118-122,149
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of electrocardiogram parameters combined with serum microRNA(miR)-322 and miR-568 levels in patients with chronic heart failure(CHF)complicated with ventricular arrhythmias(VA).Methods A total of 230 CHF patients admitted to Zhangjiakou First Hospital from April 2020 to April 2023 were selected as the study objects,including 120 VA patients(VA group)and 110 non VA patients(non VA group),and 110 patients who underwent health examinations in Zhangjiakou First Hospital during the same period as the control group.Compared three sets of general information,electrocardiogram parameters,left ventricular ejection fraction(LVEF),cardiac function grade and serum miR-322 and miR-568 levels.Logistic regression analyzed the influencing factors of VA in CHF patients.Receiver operating characteristic curve(ROC)analyzed electrocardiogram parameters combined with serum miR-322 and miR-568 for the diagnostic value of VA in CHF patients.Results The three groups showed statistically obvious differences in classification of nyha heart function(NYHA)and left ventricular ejection fraction(LVEF)(F=6.033,691.853,all P<0.05).The electrocardiogram parameters of CHF patients,including QT interval dispersion(QTD),QRS wave duration and corrected QT systolic time(QTc)were obviously higher than those in the control group(t=16.539,17.709,14.414),and the VA group were obviously higher than the non VA group(q=10.984,7.794,10.174),and the differences were statistically significan(all P<0.05).The serum levels of miR-322 and miR-568 were obviously lower than those in the control group(t=23.719,17.359).and the VA group were obviously lower than the non VA group(q=10.345,9.941),the differences were statistically significant(all P<0.05).Logistic regression analysis showed that NYHA grading,LVEF,QTD,QRS,wave duration,QTc,serum miR-322 and miR-568 levels were all influencing factors in the complication of VA in patients with CHF(Wald χ2=4.267～9.839,all P<0.05).The combination of electrocardiogram parameters and serum miR-322,miR-568 was better diagnosing CHF patients with concurrent VA that QTD,QRS duration,QTc and serum miR-332,miR-568 were measured separately.Conclusion Serum levels of miR-322 and miR-568 are obviously reduced,and the combination of electrocardiogram parameters with serum miR-322 and miR-568 has high diagnostic value for CHF patients with VA.
