The Scientific Connotation of the Pathogenesis of"Dysfunction of Spleen Transforming Essences"in Colorectal Cancer Based on"Epigenetic-Reprogramming of Glucose Metabolism"
10.11842/wst.20231121005
- VernacularTitle:基于"表观遗传-糖代谢重编程"论结直肠癌"脾不散精"病机的科学内涵
- Author:
Xiumei FAN
1
;
Wenbo HUANG
;
Xueke LI
;
Fengming YOU
;
Fang LI
;
Chong XIAO
Author Information
1. 成都中医药大学附属医院 成都 610072
- Publication Type:Journal Article
- Keywords:
Reprogramming of glucose metabolism;
Epigenetics;
Dysfunction of spleen transforming essences;
promoting spleen and dispersing essences
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2025;27(2):460-465
- CountryChina
- Language:Chinese
-
Abstract:
The key link to colorectal cancer progression is that epigenetic derangements promote reprogramming of glucose metabolism.Based on many studies on the relationship between spleen being the origin of acquired constitution and epigenetics,spleen qi dispersing essence and glucose metabolism,combined with the extensive experience of traditional Chinese medicine in the treatment of colorectal cancer and the accumulation of researches on glucose metabolism,it is believed that the"epigenetic-reprogramming of glucose metabolism"pathology of colorectal cancer is the microscopic essence of the key pathogenesis of"dysfunction of spleen transforming essences".The"promoting spleen and dispersing essences"method means that"promoting spleen"to reverse epigenetic derangements and"dispersing essences"to regulate reprogramming of glucose metabolism was put forward to treat colorectal cancer.Look forward to enrich the scientific connotation of the pathogenesis of"dysfunction of spleen transforming essences",new ideas and potential empirical basis for traditional Chinese medicine intervention in colorectal cancer were provided.
