Research Progress of Intestinal Flora Imbalance in IgA Nephropathy Based on"Gut-kidney Axis"
- VernacularTitle:基于"肠肾轴"探讨肠道菌群失调在IgA肾病的研究进展
- Author:
Xiaoqing ZHENG
1
;
Ying DING
;
Shanshan XU
;
Ting GUO
Author Information
- Publication Type:Journal Article
- Keywords: IgA nephropathy; Intestine-kidney axis; Alteration of intestinal flora; Mucosal immunity; Intestinal microecology; Research progress
- From: World Science and Technology-Modernization of Traditional Chinese Medicine 2025;27(2):446-451
- CountryChina
- Language:Chinese
- Abstract: Objective To explore the relationship between IgA nephropathy(IgAN)and intestinal flora and mucosal immune response disorder based on the theory of"intestinal-kidney axis",and to summarize and enumerate the measures of Chinese and Western medicine in the treatment of IgAN by regulating intestinal flora,mucosal immune response and improving intestinal microecology.Methods Through literature search,the changes of intestinal flora between healthy people and IgAN patients and their effects on intestinal mucosal immunity were compared and analyzed,and then the relationship between different intestinal flora and IgAN was summarized.Results This paper summarizes that different floras including Firmicutes,Escherichia coli,Bifidobacterium and Enterococcus faecalis are closely related to the occurrence and development of IgAN.Conclusions Intestinal flora imbalance can negatively regulate IgAN,regulate intestinal flora and improve intestinal microecological environment,which may become a new target for the treatment of IgAN.
