Cerebral blood flow changes in type 2 diabetes mellitus and its relationship with cognitive function based on MRI arterial spin labeling technique
10.3760/cma.j.cn112149-20240511-00268
- VernacularTitle:基于MRI动脉自旋标记技术研究2型糖尿病脑血流量变化及其与认知功能的关系
- Author:
Yuna CHEN
1
;
Saimei LI
;
Huiying LI
;
Shijun QIU
Author Information
1. 广州中医药大学第一附属医院影像科，广州 510405
- Publication Type:Journal Article
- Keywords:
Magnetic resonance imaging;
Diabetes mellitus, type 2;
Cerebral blood flow;
Cognitive function
- From:
Chinese Journal of Radiology
2025;59(1):77-83
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate cerebral blood flow (CBF) changes in type 2 diabetes mellitus (T2DM) and its relationship with cognitive function by arterial spin labeling (ASL).Methods:This study was a cross-sectional study. Clinical data (age, sex, years of education, body mass index) and imaging data of 46 patients with T2DM (T2DM group) and 57 healthy controls (HC group), who visited the First Affiliated Hospital of Guangzhou University of Chinese Medicine from September 2017 to March 2019 were analyzed retrospectively. All subjects underwent clinical cognitive function assessments, including the auditory verbal learning test (AVLT), trail making test (TMT), and montreal cognitive assessment (MoCA) scale. All subjects underwent routine axial 3D-ASL imaging, and CBF pseudocolor images were automatically generated from the 3D-ASL raw images. CBF values in the differential brain regions were extracted. The differences in clinical data, cognitive function scores, and CBF values between T2DM group and HC group were evaluated using independent sample t-tests, Mann-Whitney U tests, and χ 2 tests. The correlation between the differential brain region CBF values and cognitive function scores was analyzed using partial correlation analysis, controlling for age, gender, and years of education. Results:There were no significant differences in age, gender, years of education, AVLT scores, and TMT scores between T2DM group and HC group ( P>0.05). But there were significant differences in body mass index and MoCA scores ( Z=-2.16, P=0.031; Z=-3.18, P=0.001). Compared with HC group, T2DM group showed significantly increased CBF in the left insula ( P<0.001), but significantly decreased CBF in the right fusiform gyrus, right cuneus, and right prefrontal gyrus ( P<0.001). The partial correlation analysis showed that the CBF value in the right prefrontal gyrus of T2DM group was positively correlated with MoCA scores ( r=0.330, P=0.001), while the CBF value in the right fusiform gyrus was positively correlated with MoCA scores ( r=0.210, P=0.034). Conclusions:Patients with T2DM show changes in CBF in the left insula, right fusiform gyrus, right cingulate anterior, and right prefrontal cortex. Reduced CBF in the right prefrontal cortex and right fusiform gyrus is associated with cognitive function decline.
