Advances in the study of gut-derived uremic toxins and vascular calcification
10.20039/j.cnki.1007-3949.2025.01.011
- VernacularTitle:肠源性尿毒症毒素与血管钙化机制进展
- Author:
Meng HE
1
;
Shu RONG
1
Author Information
1. 上海交通大学医学院附属第一人民医院肾内科,上海市 200080
- Publication Type:Journal Article
- Keywords:
uremic toxins;
vascular calcification;
chronic kidney disease;
intestinal flora
- From:
Chinese Journal of Arteriosclerosis
2025;33(1):75-84
- CountryChina
- Language:Chinese
-
Abstract:
As a common complication of chronic kidney disease(CKD),vascular calcification(VC)significantly increases the incidence of CKD-complicated cardiovascular disease(CVD)and mortality.As chronic kidney disease ad-vances and the glomerular filtration rate(GFT)declines,certain solutes,incapable of efficient filtration and elimination,a-mass within the body,coalescing into uremic toxins which instigate a spectrum of complications,ultimately intensifying mortality rates.Gut-derived uremic toxins(GUT),products of intestinal flora metabolizing and fermenting intestinal sub-stances,significantly influence the trajectory and prognosis of CKD patients,exerting a pivotal role in the genesis of VC.Manipulating uremic toxin levels by modulating the host gut microbiota emerges as a potential means to prevent and manage VC.This discourse delves into elucidating the precise mechanisms through which various commonplace GUT—encompas-sing small molecules,macromolecules,and protein-bound toxins—impact the evolution of VC.This impact is predomi-nantly observed through their modulation of the host's inflammatory response,oxidative stress,and signaling pathways.These insights offer a potential avenue for the modulation of uremic toxin levels,positing a novel adjunctive therapeutic ap-proach for managing VC.
