The effect of cumulative non-high density lipoprotein cholesterol/high density lipo-protein cholesterol exposure on atherosclerotic cardiovascular disease
10.20039/j.cnki.1007-3949.2025.01.009
- VernacularTitle:累积非高密度脂蛋白胆固醇/高密度脂蛋白胆固醇暴露对动脉粥样硬化性心血管疾病的影响
- Author:
Luqing LIU
1
;
Meixiao WANG
;
Shihe LIU
;
Xiaoxue ZHANG
;
Yixiu CHEN
;
Zhihui LIU
;
Shouling WU
;
Yuntao WU
Author Information
1. 华北理工大学研究生院,河北省唐山市 063210;华北理工大学附属开滦总医院,河北省唐山市 063000
- Publication Type:Journal Article
- Keywords:
non-high density lipoprotein cholesterol/high density lipoprotein cholesterol;
cumulative exposure;
atherosclerotic cardiovascular disease;
epidemiology;
influencing factor
- From:
Chinese Journal of Arteriosclerosis
2025;33(1):58-67
- CountryChina
- Language:Chinese
-
Abstract:
Aim To investigate the effect of cumulative non-high density lipoprotein cholesterol/high density lip-oprotein cholesterol(non-HDLC/HDLC)exposure on atherosclerotic cardiovascular disease(ASCVD).Methods A prospective cohort study was conducted.A total of 50 777 employees of Kailuan Group who participated in three physical examinations in 2006-2007,2008-2009 and 2010-2011 were selected as the study subjects.Groups were divided into Q1,Q2,Q3 and Q4 according to the cumulative non-HDLC/HDLC exposure quartiles.Kaplan-Meier curve was used to calculate the cumulative incidence of ASCVD in different cumulative non-HDLC/HDLC groups,and Log-rank test was used to compare the differences among groups.Cox proportional risk model was used to analyze the effect of cumulative non-HDLC/HDLC exposure on ASCVD.Results The average follow-up was(10.19±2.21)years,and 5 003 new cases of ASCVD occurred.The cumulative incidence of ASCVD in groups Q1 to Q4 was 6.49％,8.71％,10.86％and 14.85％,respectively(Log-rank P＜0.01).Multivariate Cox regression analysis showed that compared with group Q1,the HR(95％CI)of ASCVD in groups Q2,Q3 and Q4 were 1.13(1.03～1.24),1.18(1.07～1.29),1.22(1.12～1.34),respectively;the HR(95％CI)of myocardial infarction were 1.15(0.87～1.53),1.44(1.10～1.88),1.67(1.29～2.17),respectively;the HR(95％CI)of revascularization were 1.21(0.99～1.49),1.31(1.07～1.60)and 1.49(1.22～1.81),respectively;the HR(95％CI)of ischemic stroke were 1.17(1.03～1.32),1.17(1.04～1.33)and 1.21(1.06～1.37),respectively;but the above association was not found when heart failure and atrial fibrillation were used as the outcome events.The restricted cubic spline showed that cumulative non-HDLC/HDLC values were line-arly associated with the risk of ASCVD.Conclusion Cumulative non-HDLC/HDLC exposure was positively associated with the risk of ASCVD.
