A comparison and prediction study of wide-field swept-source optical coher-ence tomography angiography in identifying non-perfusion areas in diabetic retinopathy
10.13389/j.cnki.rao.2025.0037
- VernacularTitle:广域扫频源OCTA对糖尿病视网膜病变无灌注区识别的对比及预测研究
- Author:
Chuyun GUO
1
;
Yue HAN
;
Li CHEN
;
Yi LIU
;
Hongzhuang CHENG
;
Xinru NING
;
Yadan SHEN
;
Ruolan LING
;
Jie ZHONG
;
Jie LI
Author Information
1. 610072 四川省成都市,电子科技大学医学院四川省人民医院眼科
- Publication Type:Journal Article
- Keywords:
diabetic retinopathy;
non-perfusion area;
optical coherence tomography angiography;
ultra-wide-field fluorescein angiography
- From:
Recent Advances in Ophthalmology
2025;45(3):211-215
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the differences between swept-source optical coherence tomography angiography(SS-OCTA)and ultra-wide-field fluorescein angiography(UWFA)in detecting non-perfusion areas(NPs)in patients with diabetic retinopathy(DR),to evaluate the accuracy of SS-OCTA in predicting NPs outside its visible range,and to explore the distribution patterns of NPs.Methods A retrospective analysis was made on 69 DR patients(88 eyes)who under-went both UWFA and SS-OCTA examinations at the Ophthalmology Department of Sichuan Provincial People's Hospital from December 2022 to September 2024.Manual NP labeling was conducted to compare the detection rate of NPs between the two imaging techniques.The distribution patterns of NPs and the accuracy of SS-OCTA for predicting NPs outside its visible range were also analyzed.Results In a scanning area of 20 mm x 24 mm,the overall NP detection rate by SS-OCTA was 47.40％,with UWFA taken as the standard.The NP detection rate by SS-OCTA was 51.56％in the superotemporal quad-rant,58.35％in the inferotemporal quadrant,45.50％in the superonasal quadrant,and 43.17％in the inferonasal quad-rant.Most NPs occurred in the inferonasal quadrant,accounting for 41.71％of the total NP.The accuracy of SS-OCTA in predicting NPs was 75.00％in the superonasal quadrant and 78.41％in the inferonasal quadrant.The ischemic indices(ISI)of the two imaging techniques were highly positively correlated(r2=0.74).Conclusion Although SS-OCTA can-not yet fully replace UWFA for NP detection in DR patients due to a small visible range,it is still an effective tool to assess retinal ischemia.SS-OCTA has the ability to predict NPs outside its visible range in its scanning range.The inferonasal quadrant is the region where NPs occur most frequently in DR patients,so it is suggested that special attention should be paid to this region in early diagnosis and follow-up periods.
