Exploring the Mechanism of Gastrointestinal Tumor Treatment from the Perspective of Dampness Pathogen Theory Based on Inflammatory-Metabolic-Immune Microenvironment
10.11842/wst.20240710001
- VernacularTitle:基于肿瘤炎性-代谢-免疫微环境探讨胃肠肿瘤从湿邪论治的作用机制
- Author:
Yinggang TANG
1
;
Tongfei QI
;
Guilin AN
;
Lan HE
;
Yilan JIANG
;
Qimei WANG
;
Yingchun HE
Author Information
1. 湖南中医药大学 长沙 410208
- Publication Type:Journal Article
- Keywords:
Dampness pathogen;
Inflammatory microenvironment;
Metabolic microenvironment;
Immune microenvironment;
Gastrointestinal tumor
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2025;27(2):466-473
- CountryChina
- Language:Chinese
-
Abstract:
Tumor microenvironment(TME)includes inflammatory,metabolic,and immune microenvironment,which interact in a complex network,influencing tumorigenesis,progression,and metastasis.Clinical studies on traditional Chinese medicine(TCM)have found that dampness pathogen plays a significant role in gastrointestinal precancerous lesions,tumorigenesis,and metastasis.It disrupts the gastrointestinal tumor's inflammatory,metabolic,and immune microenvironments,promoting tumor development through various mechanisms.Based on the theory of dampness pathogen,it is proposed to eliminate dampness combined with detoxification to regulate tumor inflammatory microenvironment;invigorate qi,warm yang,and remove dampness to regulate metabolic microenvironment;and strengthen the spleen,support vital energy,and dispel dampness to improve immunosuppressive microenvironment.Treating gastrointestinal tumors from the perspective of dampness pathogen theory can offer new insights and focus areas for clinical diagnosis and treatment,as well as directions for research into the molecular mechanisms of compound Chinese herbal formulas.
