Clinical case analysis: thrombocytopenia-mitral valve neoplasm-repeated limb numbness
10.3760/cma.j.cn141217-20241013-00295
- VernacularTitle:临床病例评析—血小板减少-二尖瓣赘生物-右侧肢体麻木
- Author:
Jun LI
1
;
Can HUANG
1
;
Yangzhong ZHOU
1
;
Jiuliang ZHAO
1
;
Yan ZHAO
1
;
Mengtao LI
1
Author Information
1. 中国医学科学院 北京协和医学院 北京协和医院风湿免疫科，北京 100730
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus, systemic;
Antiphospholipid syndrome;
Antiphospholipid antibodies;
Valvular vegetations;
Cerebral infarction
- From:
Chinese Journal of Rheumatology
2025;29(9):764-769
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To improve clinical understanding of secondary antiphospholipid antibody (aPLs) related multiple organ damage in systemic lupus erythematosus (SLE).Methods:A woman of reproductive age, admitted to Peking Union Medical College Hospital in June 2023, presented with recurrent disease manifestation, this case of SLE with secondary APS with multiple systems involvement such as the hematological system, heart valves, and nervous system was reported. The diagnosis and treatment process were discussed and analyzed.Results:A woman of reproductive age presented with recurrent symptoms. Initially, she was clinically diagnosed with idiopathic thrombocytopenic purpura. Over the course of the disease, she subsequently developed chronic renal insufficiency, mitral valve vegetations, and recurrent episodes of acute stroke. Laboratory investigations revealed positivity for antinuclear antibodies and aPLs. Her condition was generally improved after standardized anticoagulation therapy combined with intensive immunosuppressive treatment.Conclusion:In the context of SLE, elucidating whether the mechanisms underlying organ involvement are associated with aPLs is of significant importance for understanding the pathogenesis of the disease and guiding therapeutic strategies.
