Exploring the Current Status of Research on the Mechanism of Acupuncture Intervention in Alzheimer's Disease in Animal Experiments Using Visual Analysis Methods
10.11842/wst.20240414001
- VernacularTitle:基于可视化分析方法探究动物实验中针刺干预阿尔茨海默病的作用机制研究现状
- Author:
Jiheng ZUO
1
;
Xuan YANG
;
Donghua LI
;
Zidong WANG
;
Zhigang LI
;
Huiling TIAN
Author Information
1. 首都医科大学中医药学院 北京 100069
- Publication Type:Journal Article
- Keywords:
Mechanism;
Acupuncture;
Alzheimer's disease;
Experimental research;
Visualization
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2025;27(2):346-354
- CountryChina
- Language:Chinese
-
Abstract:
Objective In this paper,CiteSpace(V6.3.R1)was used to sort out and summarize the experimental study on the mechanism and development trend of acupuncture intervention in Alzheimer's disease(AD),so as to provide basis and suggestions for subsequent research.Methods Relevant literatures on the mechanism of acupuncture intervention in AD were retrieved from CNKI database from March 1997 to March 2024.CiteSpace(V6.3.R1)software was used to visually display keywords,draw corresponding maps,and discuss the hot spots of acupuncture intervention mechanism in AD.Results After screening,a total of 397 articles were included in this study.The mechanism of acupuncture intervention in AD mainly focuses on the regulation of synaptic plasticity,regulation of neurotransmitter release,regulation of neuroinflammation,regulation of apoptosis,influence on mitochondrial autophagy,anti-oxidative stress and so on.Conclusion Acupuncture intervention in AD has developed rapidly,involving Notch1/Hes signaling pathway,Shh signaling pathway,NF-κB signaling pathway,PI3K/Akt signaling pathway and other signaling pathways.The research heat of TCM acupuncture intervention in AD continues to rise,and various research teams have harvested rich research results,diversified research hotspots,and in-depth exploration of acupuncture treatment of AD has rich clinical value.
