Analysis of clinical characteristics and prognostic factors related to ischemic stroke in patients with systemic lupus erythematosus
10.3760/cma.j.cn141217-20241220-00372
- VernacularTitle:系统性红斑狼疮患者缺血性脑卒中的临床特点及预后相关因素分析
- Author:
Lingyao LI
1
;
Xinxin ZHANG
;
Le ZHANG
;
Ni ZHANG
;
Yan GUO
;
Yanjie SHI
;
Xin LI
;
Jing WANG
;
Lingfei MO
;
Yuanyuan LI
;
Hanchao LI
;
Xiuyuan FENG
Author Information
1. 西安交通大学第一附属医院风湿免疫科，西安 710061
- Publication Type:Journal Article
- Keywords:
Lupus erythematosus, systemic;
Ischaemic stroke;
Clinical characteristics;
Prognosis;
Associated factors
- From:
Chinese Journal of Rheumatology
2025;29(9):736-740
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To summarize and analyze the clinical characteristics of systemic lupus erythematosus (SLE) combined with ischaemic stroke and the factors associated with poor prognosis.Methods:A total of 50 patients with SLE combined with ischaemic stroke in the First Affiliated Hospital of Xi′an Jiaotong University from January 2014 to June 2024 were included in the study, the clinical data of the patients were retrospectively collected and summarized, the Shapiro-Wilk test was used to assess the normality of data, and the factors related to poor prognosis were analyzed by logistic regression analyses.Results:Fifty patients with SLE combined with ischaemic stroke had a mean age of (47.1±15.5)years, 80.0%(40/50) were female, the duration of SLE was (5.6±6.3)years, the mean SLEDAI-2K score was (14.3±4.1), the rate of anticardiolipin antibody positivity was 30.0%(15/50), and the rate of β 2-glycoprotein Ⅰ antibody positivity was 28.0%(14/50). The most common clinical manifestations of stroke were impaired limb movement (34.0%) (17/50), cerebral infarction mainly in the cerebral hemisphere (82.0%)(41/50), combined with cerebral haemorrhage in 6.0%(3/50), cerebral leukoencephalopathy in 26.0%(13/50), and cerebral atrophy in 24.0%(12/50). In terms of treatment, the most used immunosuppressant was cyclophosphamide (34.0%, 17/50), 64.0%(32/50) of patients received aspirin, 32.0%(16/50) received clopidogrel and 14.0%(7/50) received anticoagulation. Four deaths and 12 cases of severe disability were found in 50 patients at follow-up, and SLEDAI-2000 scores were positively correlated with the above poor prognosis using univariate [ OR(95% CI)=1.407(1.123,1.764), P=0.003] and multivariate [ OR(95% CI)=1.388(1.097, 1.756), P=0.006] regression analyses. Conclusion:Patients with SLE combined with ischaemic stroke had high disease activity in SLE, and SLEDAI-2000 scores were positively associated with poor prognosis of death and severe disability.
