Analysis for diagnostic value of laboratory indicators inGuillain-Barre syndrome
10.13602/j.cnki.jcls.2025.02.05
- VernacularTitle:吉兰-巴雷综合征实验室检测指标诊断价值分析
- Author:
Xuewen ZHENG
1
;
Shilan XU
1
;
Guoye LIU
1
;
Wanqing ZHOU
1
Author Information
1. 南京大学医学院附属鼓楼医院检验科,南京 210008
- Publication Type:Journal Article
- Keywords:
Guillain-Barre syndrome;
cerebrospinal fluid protein-cell separation phenomenon;
cerebrospinal fluid immunoglobulin G;
cerebrospinal fluid albumin;
serum immunoglobulin G
- From:
Chinese Journal of Clinical Laboratory Science
2025;43(2):102-105
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the diagnostic value of the phenomenon of protein-cell separation in cerebrospinal fluid(CSF),as well as the single and combined detections of CSF immunoglobulin G(CSF-IgG),CSF albumin(CSF-ALB)and serum immunoglobu-lin G(S-IgG)for Guillain-Barre syndrome(GBS).Methods A retrospective analysis was conducted on the clinical data of 65 GBS patients(GBS group)and 65 patients with other neurological diseases(non-GBS group).CSF and serum samples were collected from both the groups to analyze the diagnostic efficacy of protein-cell separation phenomenon in CSF,as well as the single and combined de-tections of CSF-IgG,CSF-ALB,and serum-IgG(S-IgG)in GBS.Results CSF protein-cell separation phenomenon was observed in 60.00％(39/65)of GBS patients.Prodromal events were presented in 67.69％(44/65)of GBS patients,which mainly were upper re-spiratory tract infection(43.08％,28/65),digestive tract infection(9.23％,6/65),and herpetic virus infection(7.69％,5/65).The levels of CSF-IgG,CSF-ALB,and S-IgG in the GBS group were significantly higher than those in non-GBS group(P＜0.05).The areas under the ROC curves(AUCROC)for single CSF-IgG,CSF-ALB,S-IgG,protein-cell separation phenomenon IN CSF,and the combination of all the four parameters in diagnosis of GBS were 0.754,0.705,0.682,0.708,and 0.840,respectively.The diagnostic specificities were 87.7％,75.4％,87.7％,81.5％,and 96.9％,respectively.Conclusion Most of the GBS patients were found to have CSF protein-cell separation phenomenon and history of prodromal infection.CSF-IgG,CSF-ALB,S-IgG,and CSF protein-cell separation phenomenon exhibited independent diagnostic value for GBS.The combined detection of the four indicators could improve the diagnostic efficacy for GBS.
