Prognostic value of mitochondrial MT-ND family genes in cancer based on a pan-cancer analysis
- VernacularTitle:基于泛癌分析的线粒体MT-ND家族基因在癌症中的预后价值
- Author:
Hai-jia ZHANG
1
;
Si CHEN
1
;
Cheng CHANG
1
;
Kai-yue GAO
1
;
Li-jie WANG
1
Author Information
- Publication Type:Journal Article
- Keywords: MT-ND family; pan-cancer; TCGA; prognostic factor; tumor microenvironment
- From: Journal of Regional Anatomy and Operative Surgery 2025;34(5):395-400
- CountryChina
- Language:Chinese
- Abstract: Objective To explore the abnormal expression of the MT-ND family in pan-cancers and its prognostic value.Methods Transcriptome expression and clinical data of 33 cancers were downloaded from the TCGA database,thereby analyzing the expression differences of the MT-ND family in tissuesof different types of cancers and normal tissues.The prognostic role of the MT-ND family in pan-cancers was explored by univariate Cox regression analysis and Kaplan-Meier survival analysis.Results The expression of the MT-ND family was upregulated in the kidney chromophobe,acute myeloid leukemia and thymoma,and downregulated in the remaining tumors.The expression of the MT-ND family was associated with the overall survival rate of different types of cancers.In addition,the MT-ND family were significantly correlated with the immune invasion subtypes,and were correlated with stromal cell invasion and tumor cell stemness to varying degrees.The expression of MT-ND4 was downregulated in brain lower grade glioma,which was a protective factor for prognosis;while the expression of MT-ND4 in thymoma was upregulated,which was a risk factor for prognosis.Conclusion Pan-cancer analysis has confirmed that the MT-ND family can predict the tumor prognosis,which provides new ideas and strategies for the precision treatment and prognostic management of cancer.
