Clinical characteristics analysis of patients with granulomatous mastitis and erythema nodosum
10.3760/cma.j.cn141217-20240522-00165
- VernacularTitle:肉芽肿性乳腺炎并结节性红斑患者的临床特征分析
- Author:
Haihui GAO
1
;
Lei ZHAO
1
;
Lin PAN
1
;
Liqin WANG
1
;
Jing DONG
1
Author Information
1. 青岛大学附属医院风湿免疫科，青岛 266000
- Publication Type:Journal Article
- Keywords:
Granulomatous mastitis granulomatous mastitis;
Erythema nodosum erythema nodosum;
Arthritis arthritis
- From:
Chinese Journal of Rheumatology
2025;29(1):48-51
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To describe the clinical characteristics of a possible rare syndrome, the granulomatous mastitis(GM), erythema nodosum and arthritis syndrome (GMENA syndrome), by retrospective analyzing patients with both GM and erythema nodosum, with or without arthritis, and provide clinical evidence for further researchstudy.Methods:This study analyzed the demographic general information, clinical manifestations, laboratory tests results, medications, operations, and the first visits of cases collected from the Affiliated Hospital of Qingdao University between January 2015 and February 2024. All patients were diagnosed with both GM and erythema nodosum, with or without arthritis. The frequency, means and standard deviation were used to perform descriptive analysis.Results:Among the 22 cases, all of the GM were unilateral, and nodular erythema mainly appeared in both lower limbs 17 (77%). Eight (67%) patients had arthritis. Sixteen cases (80%) were reported forwith elevated white blood cells count, and 16 (84%) with elevated C-reactive protein level, 12(86%) patients were with elevated erythrocyte sedimentation rate. Two cases were associated with hyperprolactinemia. In the bacterial tests of the breast abscess, C orynebacterium kroppenstedtii, and one Staphylococcus epidermidis were detected in 1 case respectively. The department of breast surgery was the most frequently first visit (86%) medical service, and 14 cases (64%) visited the department of rheumatology and immunology. Four cases (18%) underwent abscess incision and drainage after ineffective medication and none of them were treated with glucocorticoids. Five cases with glucocorticoids and followed-up by the department of rheumatology and immunology were not operated and four in of them without recurrenc. Conclusion:GMENA syndrome may be a syndrome characterized by high inflammatory activity, cytokine activation, and often involves the breast, skin, and joint. The pathogenesis and treatment of this syndrome need to be investigated further.
