Progress in role and expression regulation of asprosin in metabolic syndrome
10.3969/j.issn.1000-4718.2025.05.021
- VernacularTitle:白脂素在代谢综合征中作用及其表达调控的研究进展
- Author:
Jie REN
1
;
Zhifang REN
1
;
Rui LIU
1
;
Jie QIN
1
Author Information
1. 山西医科大学第五临床医学院内分泌科,山西 太原 030012
- Publication Type:Journal Article
- Keywords:
asprosin;
metabolic syndrome;
obesity;
diabetes mellitus
- From:
Chinese Journal of Pathophysiology
2025;41(5):1024-1029
- CountryChina
- Language:Chinese
-
Abstract:
Metabolic syndrome is a group of clinical syndromes of metabolic disorders characterized by the in-dividual clustering of various disease states such as central obesity,hypertension,dyslipidemia,abnormal glucose metabo-lism,and hyperuricemia.This syndrome not only causes an increased hospitalization rate,complication rate,and mortali-ty but also is a metabolic disorder syndrome that can affect the prognosis of other diseases.It often leads to an increased risk of cardiovascular and cerebrovascular accidents in patients.Asprosin is a novel adipokine discovered in recent years that plays a crucial role in appetite regulation,adipose tissue remodeling,inflammatory response,and oxidative stress.More and more studies have found that asprosin is involved in the development of obesity and related metabolic syndrome,as well as its role in metabolic disorders such as diabetes and its chronic complications,insulin resistance,nonalcoholic fatty liver disease,and polycystic ovary syndrome.In this paper,we review the regulatory effect and mechanism of aspro-sin in obesity and related metabolic syndrome.We further elaborate on its regulatory mechanism and research status on metabolic disorders,providing new targets and ideas for improving obesity and other related metabolic diseases.
