Progress in repair of intestinal barriers through treatments with natural products in ulcerative colitis
10.3969/j.issn.1000-4718.2025.00.011
- VernacularTitle:天然产物修复肠道屏障缓解溃疡性结肠炎的研究进展
- Author:
Shuhong ZHANG
1
;
Xiaqing WU
1
;
Hongjuan WANG
1
;
Huan CHEN
1
;
Hong-wei HOU
1
;
Qingyuan HU
1
Author Information
1. 北京生命科技研究院,北京 102209;国家烟草质量监督检验中心,烟草生物学效应重点实验室,河南 郑州 450001
- Publication Type:Journal Article
- Keywords:
natural products;
ulcerative colitis;
intestinal barrier;
mechanism
- From:
Chinese Journal of Pathophysiology
2025;41(5):1014-1023
- CountryChina
- Language:Chinese
-
Abstract:
Ulcerative colitis(UC)is a chronic inflammatory bowel disease affecting the colon(particularly the descending colon and sigmoid)and rectum.UC primarily presents with persistent or recurrent diarrhea,abdominal pain,bloody stools,and other symptoms.The primary pathological mechanism of UC involves intestinal barrier injury.When the intestinal barrier function is compromised,characterized by loss of epithelial layer integrity,thinning of the mucus layer,and microbiota dysregulation,pathogenic microorganisms can infiltrate the lamina propria from the intestinal lumen through the damaged barrier,triggering and exacerbating the intestinal inflammatory response.Current treatments for UC are limited by high costs,numerous adverse reactions,and a high likelihood of relapse.Consequently,there is an urgent need for the development of new drugs that can effectively and safely treat UC.Natural products have become significant research targets in treating various diseases due to their broad biological activity,multiple action targets,low toxicity,and easy availability.They play a crucial role in the targeted repair of the intestinal barrier,with potential mechanisms including enhancing intes-tinal epithelial cells and their secreted proteins,regulating gut microbiota and its metabolism,and balancing immune cell subsets.Additionally,it is essential to consider the synergistic effects,bioavailability,and safety of natural products.This paper summarizes the natural products reported in the past five years for their anti-UC properties by repairing the intestinal barrier,providing a theoretical basis for the development and application of natural products in anti-UC drugs.
