Progress of PANoptosis and tumors
10.3760/cma.j.cn115355-20240526-00270
- VernacularTitle:泛凋亡与肿瘤的研究进展
- Author:
Fengling YAO
1
;
Hong WEN
1
;
Xiaoxia HUO
1
Author Information
1. 河北医科大学第二医院鹿泉院区消化内科，石家庄 050000
- Publication Type:Journal Article
- Keywords:
Programmed cell death;
PANoptosis;
Neoplasms
- From:
Cancer Research and Clinic
2025;37(4):317-320
- CountryChina
- Language:Chinese
-
Abstract:
Cell death is divided into uncontrolled accidental cell death (ACD) and controllable regulatory cell death (RCD). RCD is also known as programmed cell death (PCD) under physiological conditions. PANoptosis is a recently discovered inflammatory RCD pathway regulated by a cytoplasmic polymeric protein complex called PANoptosome. This complex has the key features of apoptosis, pyrodeath, and/or necrotic apoptosis, but cannot be explained by any of these 3 RCD pathways alone. However, the specific role of PANoptosis in human tumor cells remains to be clarified. At present, the understanding of the molecular mechanism of PANoptosis and the assembly of PANoptosome is very limited, but several important regulatory targets have been identified such as melanoma deficiency factor 2 (AIM2), caspase family members(including CASP3, CASP6, and CASP8), Z-DNA-binding protein 1 (ZBP1), receptor-interacting protein kinase 1/3 (RIPK1/3) and interferon regulatory factor 1 (IRF1). The discovery of these markers indicates a breakthrough for the optimization of cancer treatment strategies.
