Research progress on the molecular mechanism of the relationship between macrophages and acute ischemic stroke
10.3969/j.issn.1672-5921.2025.04.009
- VernacularTitle:巨噬细胞与急性缺血性卒中关系的分子机制研究进展
- Author:
Yongshun ZHANG
1
;
Feng ZHAO
1
;
Meng SUN
1
;
Zhiqiang LI
1
Author Information
1. 071000 河北省保定市,河北大学附属医院介入血管外科
- Publication Type:Journal Article
- Keywords:
Macrophage;
Acute ischemic stroke;
Exosome;
Ferroptosis;
Review
- From:
Chinese Journal of Cerebrovascular Diseases
2025;22(4):285-290
- CountryChina
- Language:Chinese
-
Abstract:
The relationship between macrophages and acute ischemic stroke is currently a research hotspot.Previous studies have shown that macrophages in the central nervous system,vascular wall,and circulatory system can affect acute ischemic stroke through different mechanisms such as exacerbating inflammatory responses,phagocytosis,or inducing ferroptosis of vascular endothelial cells.In addition,during the occurrence of acute ischemic stroke,macrophages in the vascular wall and circulating system play a significant role through exosomes.This article reviewed the pathogenic mechanisms of macrophages in acute ischemic stroke,with the aim of providing a reference for in-depth research on the relationship between macrophages and acute ischemic stroke and the development of precise treatment plans.
