Advances in antiviral drugs
10.13699/j.cnki.1001-6821.2025.02.021
- VernacularTitle:抗病毒药物的研究进展
- Author:
Yu ZHOU
1
;
Li-li HA
1
;
Jun WANG
1
Author Information
1. 国家药品监督管理局药品审评中心,北京 100076
- Publication Type:Journal Article
- Keywords:
antiviral drug;
corona virus disease 2019;
human immunodeficiency virus;
neutralizing antibody
- From:
The Chinese Journal of Clinical Pharmacology
2025;41(2):254-259
- CountryChina
- Language:Chinese
-
Abstract:
Virus are one of the main pathogens that cause many serious diseases in humans,animals and plants.Antivirals are a class of drugs specifically used to treat viral infections.Although different virus replicate in different ways,infecting the human body has several stages in common,including entry,biosynthesis,assembly,and release.Virus of the same genus are highly similar in protein structure and sequence,so they can be used as common targets for antiviral drug development.This article reviews the processes of viral infection in humans and the targeted antiviral drugs designed for these processes,including inhibitors targeting the surface subunit(SfS)and transmembrane subunit(TmS)of viral enveloped glycoprotein,viral entry inhibitors targeting host proteins,RNA-dependent RNA polymerase and RNA/DNA-dependent DNA polymerase inhibitors and virus protease inhibitors,in order to provide clues for the development of antiviral drugs for future epidemics.
