Progress of GSDME-mediated pyrodeath in tumor therapy
10.3760/cma.j.cn115355-20240411-00170
- VernacularTitle:GSDME介导的细胞焦亡在肿瘤治疗中的研究进展
- Author:
Lijia YAN
1
;
Qinmei FENG
1
Author Information
1. 山西医科大学第五临床医学院 山西省人民医院妇科，太原 030012
- Publication Type:Journal Article
- Keywords:
Pyroptosis;
GSDME;
Neoplasms
- From:
Cancer Research and Clinic
2025;37(5):389-392
- CountryChina
- Language:Chinese
-
Abstract:
The generation of drug resistance in the process of tumor treatment is the key problem that the tumor cannot continue to be effectively treated. Studies have found that the drug resistance of multiple tumors is related to GSDME. Some chemotherapeutics can further induce programmed death of drug-resistant tumor cells through GSDME protein mediated by caspase-3, which is called pyrodeath. This paper reviews some clinical studies on the treatment of GSDME-related drug-resistant tumor cells, providing new insights and ideas for further treatment of clinical drug resistance.
