Research status of insulin resistance mechanisms and the improvement of insulin resistance by active ingredients of dark plum
10.13699/j.cnki.1001-6821.2025.02.025
- VernacularTitle:胰岛素抵抗机制及乌梅活性成分改善胰岛素抵抗的研究现状
- Author:
Zhen-ni ZHANG
1
;
Wen-fang JIN
;
Hu-gang JIANG
;
Xin-qiang WANG
;
Kai LIU
;
Ying-dong LI
;
Xin-ke ZHAO
Author Information
1. 甘肃中医药大学中西医结合学院,甘肃兰州 730000
- Publication Type:Journal Article
- Keywords:
dark plum;
active ingredient;
signaling pathway;
stress response;
insulin resistance
- From:
The Chinese Journal of Clinical Pharmacology
2025;41(2):274-278
- CountryChina
- Language:Chinese
-
Abstract:
Dark plum can be used to treat symptoms such as consumptive thirst due to deficiency-heat and chronic cough due to lung deficiency.Its active ingredients have auxiliary effects on lowering blood glucose,antibacterial and anti-inflammatory activities.Insulin resistance is mainly characterized by the weakening of the physiological effects of insulin in the body,with a relatively complex mechanism that can lead to various metabolic-related diseases and seriously affect health.The active ingredients of dark plum can improve insulin resistance by regulating insulin signaling pathways,endoplasmic reticulum stress,antioxidant stress,inflammatory signaling pathways,levels of related inflammatory mediators,and free fatty acid levels.By reviewing the relevant literature on the improvement of insulin resistance by the active ingredients of dark plum,this article summarizes and analyzes its mechanism of action,aiming to provide new ideas and scientific evidence for in-depth research on insulin resistance and the development and application of drugs.
