Research status of action of alkaloids in the treatment of rheumatoid arthritis
10.13699/j.cnki.1001-6821.2025.02.024
- VernacularTitle:生物碱治疗类风湿关节炎的研究现状
- Author:
Yun LI
1
;
Yu-hui WANG
1
;
Li LI
1
;
Jia-rong MA
1
;
Min ZHAO
1
Author Information
1. 甘肃中医药大学陇药产业创新研究院,甘肃兰州 730000
- Publication Type:Journal Article
- Keywords:
alkaloid;
rheumatoid arthritis;
inflammation;
mechanism of action;
research status
- From:
The Chinese Journal of Clinical Pharmacology
2025;41(2):269-273
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis(RA)is an inflammatory disease mainly associated with polyarthritis.It is mainly due to the joint swelling and joint inflammation caused by immune cells.The alkaloids in traditional Chinese medicine can reduce the level of pro-inflammatory factors and increase the level of anti-inflammatory factors,reduce the joint synovial tissue hyperplasia,inflammatory cell infiltration and new blood vessel formation,inhibit the differentiation of osteoclasts,and then play an anti-RA role.Therefore,the review used the effects and mechanisms of alkaloids for RA to inform the development of new drugs for RA.
