Progress in mechanism of kinesin superfamily proteins involved in patho-logic pain
10.3969/j.issn.1000-4718.2025.00.012
- VernacularTitle:驱动蛋白超家族参与病理性疼痛机制的研究进展
- Author:
Shujie CHEN
1
;
Tao XU
1
;
Huan JIN
1
;
Junwei ZENG
1
;
Xiaohong LIU
1
Author Information
1. 遵义医科大学生理学教研室,贵州 遵义 563000
- Publication Type:Journal Article
- Keywords:
kinesin;
pathologic pain;
spinal cord;
dorsal root ganglion
- From:
Chinese Journal of Pathophysiology
2025;41(5):1006-1013
- CountryChina
- Language:Chinese
-
Abstract:
Kinesin superfamily proteins(KIFs)are motor proteins that travel along microtubules and facilitate the transport of small biological molecules within cells.Various kinesin proteins are present in the dorsal root ganglion and spinal dorsal horn,where they modulate the excitability and sensitivity of sensory neurons,contributing to the occurrence and maintenance of pathological pain.Therefore,they represent potential therapeutic targets for the treatment of pathologi-cal pain.This review provides a comprehensive overview of the recent advancements in understanding the peripheral and central mechanisms of kinesins in the context of pathological pain,offering valuable insights for the potential development of analgesic medications targeting kinesin.
