Prevalence of brucellosis patients combined with Mycobacterium tuberculosis infection and diagnostic efficiency of different tuberculosis immunological methods
10.3760/cma.j.cn231583-20250115-00036
- VernacularTitle:布鲁氏菌病患者合并结核分枝杆菌感染情况及不同结核免疫学方法的诊断效率分析
- Author:
Zhangjun LI
1
;
Siyuan DUAN
1
;
Shiwu MA
1
Author Information
1. 中国人民解放军联勤保障部队第九二〇医院感染科，昆明 650032
- Publication Type:Journal Article
- Keywords:
Brucellosis;
Mycobacterium tuberculosis;
Infection;
Diagnostic efficiency
- From:
Chinese Journal of Endemiology
2025;44(9):758-761
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the prevalence of brucellosis patients combined with Mycobacterium tuberculosis( M. tuberculosis) and diagnostic efficiency of different tuberculosis immunological methods in screening brucellosis patients complicated with tuberculosis. Methods:A retrospective study was conducted to collect medical records of hospitalized patients diagnosed with brucellosis in the Department of Infectious Diseases 920th Hospital of Joint Logistics Support Force from January 1, 2020 to December 31, 2023, who had tuberculosis interferon gamma release assay (IGRA) examination records. The incidence of M. tuberculosis co-infection in brucellosis patients with different characteristics, as well as the diagnostic efficiency of different tuberculosis immunological methods were compared. Results:A total of 233 patients with brucellosis were included, and 63 patients with combined with M. tuberculosis infection were detected, with a combined M. tuberculosis infection rate of 27.0%. According to different characteristics, the incidence of M. tuberculosis co-infection in brucellosis patients aged > 45 years (31.9%, 52/163) was significantly higher than that in patients aged ≤45 years (15.7%, 11/70), and the difference was statistically significant (χ 2 = 6.51, P = 0.011). Among different tuberculosis immunological methods, the positive rates of IGRA, tuberculosis antibody and tuberculin skin test (TST) were 21.0% (49/233), 5.3% (12/226), and 4.9% (9/185), respectively, with statistically significant differences among the three groups (χ 2 = 38.92, P < 0.001). Conclusions:The proportion of brucellosis patients combined with M. tuberculosis infection is relatively high, and middle-aged and elderly brucellosis patients are the key population for complicated infections. When screening brucellosis patients combined with M. tuberculosis infection, the diagnostic efficiency of IGRA is significantly better than that of tuberculosis antibody and TST testing.
