Progress of cancer-associated fibroblasts in tumor angiogenesis
10.3760/cma.j.cn115355-20241101-00504
- VernacularTitle:癌相关成纤维细胞在肿瘤血管生成中的研究进展
- Author:
Qilu YAN
1
;
Yingge LI
1
;
Yi YAO
1
;
Qibin SONG
1
Author Information
1. 武汉大学人民医院肿瘤中心，武汉 430060
- Publication Type:Journal Article
- Keywords:
Cancer-associated fibroblasts;
Antiangiogenic therapy;
Molecular targeted therapy
- From:
Cancer Research and Clinic
2025;37(6):468-472
- CountryChina
- Language:Chinese
-
Abstract:
Tumor angiogenesis plays a crucial role in tumor proliferation, invasion and metastasis, representing one of the hallmarks of cancer. Cancer-associated fibroblasts (CAF), as the core component of tumor microenvironment, have a decisive impact on tumor angiogenesis. On the one hand, CAF can secrete various cytokines such as vascular endothelial growth factor and hepatocyte growth factor, which activate the related signaling pathways to promote angiogenesis; on the other hand, CAF-derived exosomes carry pro-angiogenic factors and specific microRNA that drive this process through multiple signaling cascades. In addition, CAF can also modify the extracellular matrix, create favorable conditions for angiogenesis, and interact with immune cells to promote angiogenesis by regulating macrophage polarization. Based on these mechanisms, anti-angiogenic therapy targeting CAF has become a new research hotspot, ProAgio protein, eicosapentaenoic acid and other formulations have shown potential therapeutic effects, and various biophysical therapies for CAF have also shown great potential, which are expected to bring new breakthroughs to tumor treatment in the future.
