Exploring the Impact of Compound Jinguanlan on Acne Based on the p38 MAPK Signaling Axis
10.11969/j.issn.1673-548X.2025.04.024
- VernacularTitle:基于p38丝裂原活化蛋白激酶信号轴探讨复方金贯蓝对痤疮的影响
- Author:
Yanli LIU
1
;
Jun GAO
;
Chunrui SHI
Author Information
1. 730000 兰州大学第一临床医学院
- Publication Type:Journal Article
- Keywords:
Acne vulgaris;
Compound Jinguanlan preparation;
IL-6;
TNF-α;
p38 MAPK
- From:
Journal of Medical Research
2025;54(4):136-140
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of Compound Jinguanlan preparation on acne vulgaris through the p38MAPK signaling pathway.Methods New Zealand White Rabbits were randomly divided into high,medium,and low concentration groups of Jinguanlan,a positive control group,a model control group,and a blank control group.A rabbit ear acne model was constructed and each group was given the corresponding drug intervention.The gross changes in the skin tissue of the rabbit ears were observed.HE staining was used to observe pathological changes.ELISA was used to detect the levels of IL-6 and TNF-α in the serum.Western blot was used to detec the levels of p38MAPK protein expression.Results Jinguanlan significantly inhibited the inflammation of acne vulgaris,reducing swelling,erythema,hyperkeratosis,and inflammatory cell infiltration in the rabbit ears.ELISA results showed that compared with the model control group,the levels of IL-6 and TNF-α in the serum of each concentration of Jinguanlan group were significantly reduced,with the high concentration group showing a more pronounced decrease(P＜0.01).Western blot results indicated that compared with the model group,the relative expression of p38 MAPK protein in the Jinguanlan group was reduced.Conclusion Jinguanlan can inhibit the inflammatory response of acne vulgaris,and its effect may be achieved by regulating the p38MAPK signaling pathway and reducing the expression levels of IL-6 and TNF-α in the serum.
