Exploring the Distribution and Characteristics of Cancer-related Fatigue Evidence in Children with Non-Hodgkin's Lymphoma Based on a Hidden Structural Model
10.11969/j.issn.1673-548X.2025.04.023
- VernacularTitle:基于隐结构模型探析儿童非霍奇金淋巴瘤癌因性疲乏中医证候分布及特征
- Author:
Ziqi DONG
1
;
Lu LU
;
Jing HUANG
Author Information
1. 100027 北京中医药大学东直门医院
- Publication Type:Journal Article
- Keywords:
Children;
Lymphoma;
Cancer-related fatigue;
Crypto-structural model;
Evidence
- From:
Journal of Medical Research
2025;54(4):130-135,145
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the distribution pattern of Chinese medicine symptoms in childhood non-Hodgkin's lymphoma cancer-related fatigue(CRF)and provide a basis for clinical treatment.Methods Information on the four TCM diagnoses of 103 children diagnosed with childhood non-Hodgkin's lymphoma CRF from July 2023 to July 2024 was collected from a single centre,and a database was established.Lantern 5.0software was used to analyse the characteristics of common TCM signs and symptoms of children with non-Hodgkin's lymphoma CRF by hidden structure model.Results Seventy-five high-frequency symptoms and signs,including yellow u-rine,general weakness,mental fatigue,thick and greasy moss,and irritability.Hidden structure model was constructed to obtain 5syndromes,according to which the identification rules were formulated for the secondary identification of children with CRF,and their syn-dromes types were,in descending order,heart-spleen stagnant heat,dampness-heat accumulation syndromes,qi deficiency and stasis,liver-qi stagnation syndromes,and heart-liver-blood deficiency syndromes.Conclusion The symptom types of CRF in children with non-Hodgkin's lymphoma were mainly deficiency and mixed reality syndromes,with pathological factors such as heat,stasis,dampness and accumulation on the basis of deficiency of qi,blood and yin.The study finally obtained five types of CRF in children with non-Hodgkin's lymphoma,and the distribution of the types is different from that of adults due to the influence of paediatric characteristics and pathophysiological characteristics.The treatment should be based on supporting the positive qi,and at the same time focusing on the method of eliminating food and resolving accumulation,regulating qi and diarrhoea,especially taking care of the lung,the spleen and the kidney of children.
