Correlation of genetic and epigenetic characteristics with the prognosis in patients with head and neck squamous cell carcinoma

VernacularTitle:头颈部鳞状细胞癌遗传学和表观遗传学特征与预后的相关性
Author: Yuce WEI ¹ ; Yue CHAI ¹ ; Mei DONG ¹
Author Information

1. 国家癌症中心/国家肿瘤临床医学研究中心/中国医学科学院北京协和医学院肿瘤医院内科，北京　100021
Publication Type:Journal Article
Keywords: Head and neck neoplasms; Carcinoma, squamous cell; Genetics; Epigenetics; Prognosis
From: Cancer Research and Clinic 2025;37(4):309-312
CountryChina
Language:Chinese
Abstract: Head and neck tumors are mainly classified into lesions originating from the oral cavity, pharynx, larynx, paranasal sinuses, and salivary glands. Squamous cell carcinoma remains the most common histopathological subtype. The in-depth exploration of genetics and epigenetics can contribute to elucidating the molecular mechanisms of development, progression and metastasis in head and neck squamous cell carcinoma (HNSCC), screening prognostic related biomarkers, which provide new directions and opportunities for targeted therapy. This paper summarizes the primary genetic and epigenetic characteristics of HNSCC and discusses the correlation of key molecules with the prognosis of patients.