Elderly acute progressive cerebral infarction patients' serum PLA2,called S100B levels and the relation-ship between carotid plaques
10.3969/j.issn.1006-5725.2025.02.014
- VernacularTitle:老年急性进展性脑梗死患者血清磷脂酶A2、S100钙结合蛋白B水平与颈动脉斑块的联系
- Author:
Yanyan JIA
1
;
Yijia SUN
;
Di ZHAO
;
Yan SONG
Author Information
1. 南阳市中心医院神经内科,河南南阳 473000
- Publication Type:Journal Article
- Keywords:
senile acute progressive cerebral infarction;
phospholipase A2;
S100 calcium-binding protein B;
carotid plaque
- From:
The Journal of Practical Medicine
2025;41(2):244-249
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between serum phospholipase A2(PLA2),S100 calcium-binding protein B(S100B) and carotid plaque in elderly patients with acute progressive cerebral infarction. Methods From January 2021 to June 2022,120 elderly patients with acute progressive cerebral infarction were enrolled in the study group,while 115 patients with non-progressive cerebral infarction were classified as non-progressive group and 100 healthy people as healthy group. The study group was divided into three groups:no plaque group (34 cases),stable plaque group (45 cases) and unstable plaque group (41 cases). To analyze the relationship between serum PLA2 and S100B levels and carotid plaque. ROC analysis of their predictive value for carotid plaque. Follow-up for 1 year,the survival rate was analyzed with recurrence and death as the end points. Results The levels of serum PLA2 and S100B in stable and unstable plaque groups were higher than those in non-plaque group,and the difference was statistically significant (P<0.05). Serum PLA2 and S100B were positively correlated with carotid plaque. ROC showed that the value of joint prediction was higher (P<0.05). Conclusion The levels of serum PLA2 and S100B are increased in elderly patients with acute progressive cerebral infarction,which is closely related to carotid plaque.
