Correlation between plasma ADAMTS13 level,disease severity and prognosis in patients with endometriosis
10.3969/j.issn.1006-5725.2025.02.013
- VernacularTitle:子宫内膜异位症患者血浆血管性血友病因子裂解蛋白酶水平与病情严重程度和预后的相关性
- Author:
Ke XU
1
;
Mingzhe ZHANG
;
Mingyang WANG
;
Song LIU
Author Information
1. 遵义医科大学附属医院妇科,贵州遵义 563003
- Publication Type:Journal Article
- Keywords:
endometriosis;
plasma ADAMTS13 level;
r-AFS staging;
prognosis
- From:
The Journal of Practical Medicine
2025;41(2):238-243
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between plasma von willebrand factory-lytic protease (ADAMTS13) level and the severity of the disease and its prognostic value in patients with endometriosis (EMS). Methods 130 patients with EMS treated in the hospital from January 2019 to December 2022 were retrospectively selected. Plasma ADAMTS13 level was detected by enzyme-linked immunosorbent assay (ELISA),and its correla-tion with American Fertility Society (r-AFS) stage and endometriosis Health Status Scale (EHP-30) score was analyzed. The 1-year prognosis was recorded,and the risk factors of poor prognosis were analyzed by logistic regression. Receiver operating characteristic curve (ROC) was plotted to evaluate the predictive value of plasma ADAMTS13 levels in patients with EMS. Results The plasma ADAMTS13 level of EMS patients decreased signifi-cantly with the increase of r-AFS stage,and was negatively correlated with the score of EHP-30 (P<0.001). Multiple factors showed that low plasma ADAMTS13 level,bilateral location of pelvic lesions and high r-AFS stage were independent risk factors for poor prognosis (all P<0.05). ROC analysis showed that the area under the curve (AUC) of plasma ADAMTS13 was 0.889 (cut-off point 13.315,sensitivity 0.931,specificity 0.690). Conclusion Plasma ADAMTS13 level is negatively correlated with the severity of EMS,and is an independent risk factor for poor prognosis of EMS patients,and has a certain predictive value for prognosis of EMS patients.
