Prognostic Value of APRI Combined with AIMS65score in Predicting Prognosis of Liver Cirrhosis with Upper Gastrointestinal Bleeding
10.11969/j.issn.1673-548X.2025.04.028
- VernacularTitle:APRI联合AIMS65评分对肝硬化伴上消化道出血预后的预测价值
- Author:
Yingxiu XU
1
;
Dandan ZHAO
;
Kejian WU
Author Information
1. 221000 徐州医科大学第一临床医学院
- Publication Type:Journal Article
- Keywords:
Cirrhosis;
Upper gastrointestinal bleeding;
APRI;
AIMS65score;
Prognosis
- From:
Journal of Medical Research
2025;54(4):157-163,11
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the predictive value of aspartate aminotransferase to platelet ratio index(APRI)combined with AIMS65score for death and rebleeding within 6 weeks in patients with cirrhosis with upper gastrointestinal bleeding(UGIB).Methods The clinical data of 302 patients with cirrhosis with UGIB who attended the Affiliated Hospital of Xuzhou Medical University from June 2019 to April 2024 were retrospectively collected.Binary Logistic regression was used to analyse the independent risk factors for death within 6 weeks and rebleeding.The receiver operating characteristic(ROC)curve was plotted and the area under the curve(AUC)was calculated to compare its efficacy in predicting death and rebleeding within 6 weeks.Results Univariate and multivariate Logistic regres-sion analyses showed that APRI and AIMS65score were independent risk factors for death within 6 weeks in cirrhosis with UGIB;ROC curves showed that the AUC values of APRI combined with AIMS65score were higher than those of APRI,AIMS65score,Child-Pugh score,and MELD score(P＜0.05),and their AUC values were 0.889,0.775,0.859,0.832 and 0.735.History of previous bleed-ing,APRI,and AIMS65score were independent risk factors for rebleeding within 6 weeks in cirrhosis with UGIB;ROC curves showed that the AUC values of APRI,AIMS65score,Child-Pugh score,MELD score,and APRI combined with AIMS65score had AUC values of 0.709,0.729,0.735,0.688 and 0.774,respectively.And the predictive efficacy of APRI combined with AIMS65score was better than that of APRI,AIMS65score,and MELD score(P＜0.05).Conclusion APRI and AIMS65score are independent risk factors for death and rebleeding within 6 weeks in cirrhosis with UGIB,and the combination of the two has better predictive value for the short-term prog-nosis of patients with cirrhosis with UGIB.
