Construction of Nomogram Prediction Model for Malnutrition in Patients with Lung Cancer undergoing Chemotherapy
10.11969/j.issn.1673-548X.2025.04.020
- VernacularTitle:肺癌化疗患者营养不良的列线图预测模型构建
- Author:
Zhiying SONG
1
;
Huifang WANG
1
;
Jia CHEN
1
Author Information
1. 226000 南通市肿瘤医院肿瘤内科
- Publication Type:Journal Article
- Keywords:
Lung cancer;
Chemotherapy;
Malnutrition;
Influencing factor;
Nomogram model
- From:
Journal of Medical Research
2025;54(4):111-115,156
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the influencing factors of malnutrition in patients with lung cancer undergoing chemotherapy,and construct a predictive nomogram model according to the results.Methods A retrospective analysis was made on 100 patients with lung cancer who received postoperative chemotherapy in our hospital from March 2022 to April 2024.After all the patients had completed five cycles of chemotherapy,the incidence of malnutrition was counted.According to the nutritional evaluation results,the patients were divid-ed into two groups:well-nourished group and malnourished group.The clinical data of patients were compared and the related influen-cing factors were screened by Logistic regression analysis.The nomogram model for risk prediction of malnutrition risk of lung cancer pa-tients undergoing chemotherapy was constructed,and the predictive value and fitting degree of the model were evaluated by drawing the re-ceiver operating characteristic(ROC)curve and calibration curve.Results There were 29 cases of malnutrition in 100subjects,and the other 71 patients had normal nutritional status.Among the general data with significant differences between the two groups,TNM is stageⅣ(OR=2.275,95％CI:1.242-4.169),Accompanied by digestive system adverse reactions(OR=2.142,95％CI:1.133-4.050),Low albumin(OR=2.601,95％CI:1.370-4.937),Low hemoglobin(OR=2.697,95％CI:1.483-4.903),Low prealbumin(OR=2.686,95％CI:1.460-4.941)is a risk factor for malnutrition in patients with lung cancer undergoing chemotherapy(P＜0.05).Based on the above related risk factors,a nomogram model was established to predict the occurrence of malnutrition in patients with lung cancer undergoing chemotherapy.ROC curve analysis showed that the AUC value and 95％CI of the model for predicting malnutrition in patients with lung cancer undergoing chemotherapy were 0.972 and 0.918-0.995.The calibration curve results show that the nomogram model has a good fitting degree.Conclusion TNM is stage Ⅳ,accompanied by digestive system adverse reactions,low KPS score before chem-otherapy and low levels of albumin,hemoglobin and prealbumin are all related risk factors for malnutrition in patients with lung cancer un-dergoing chemotherapy.The nomograph model based on this is also of high predictive value.
