Evaluation of Renal Function and Oxygenation Levels in Patients with Type 2Diabetes by BOLD MRI
10.11969/j.issn.1673-548X.2025.04.013
- VernacularTitle:BOLD MRI评价2型糖尿病肾功能与氧合水平的研究
- Author:
Limin ZHAI
1
;
Deyuan ZHANG
;
Tianrong PAN
Author Information
1. 230601 合肥,安徽医科大学第二附属医院内分泌科
- Publication Type:Journal Article
- Keywords:
BOLD MRI;
Diabetic kidney disease;
N-acetyl-β-D glucosidase
- From:
Journal of Medical Research
2025;54(4):64-68
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between renal function and renal tissue oxygenation in type 2diabetes patients with blood oxygenation level dependent MRI(BOLD MRI)and to explore its value in clinical and scientific research.Methods A total of 80diabetic kidney disease patients with type 2diabetes admitted to hospital from April 2023 to August 2024 were selected.According to the the ratio of urinary albumin and creatinine,the patients were divided into normal albuminuria group,microalbuminuria group and mac-roalbuminuria group.All patients were examined by BOLD MRI.R2* values of renal cortex and medulla were measured by two radiolo-gists respectively,and the mean R2*values of renal cortex and medulla,the ratio of the two values(MCR)were obtained.The consis-tency of CR2* and MR2* measured by 2 physicians and the differences of CR2*,MR2* and MCR among 3 groups were compared,and the correlation with clinical indicators were analyzed.Results There were statistically significant differences in serum creatinine and glomerular filtration rate among the three groups(P＜0.05).ACR,urinary microalbumin and urinary N-acetyl-β-D glucosaminase(UANG)were significantly different among the three groups(all P＜0.01).The fasting C-peptide based insulin resistance index(HOMA2-IR)of the three groups was significantly different(P＜0.05).BOLD MRI results showed that the differences of CR2*,MR2* and MCR among the three groups were statistically significant(all P＜0.05).Correlation analysis showed that CR2* and MR2* were positively correlated with creatinine,ACR,urinary microalbumin,UANG and HOMA2-IR,respectively,and negatively correlated with glomerular filtration rate.Conclusion BOLD MRI is a non-invasive method to evaluate oxygenation in diabetic nephrop-athy,and the R2* of cortex and medulla in renal tissue are correlated with different renal function indicators.
