Application effect of nylon rope loop closure in endoscopic full-thickness resection for gastric fundus stromal tumor
10.3760/cma.j.cn115355-20240418-00189
- VernacularTitle:尼龙绳圈套扎闭合在胃底间质瘤患者内镜下全层切除术中的应用效果
- Author:
Jiake XU
1
;
Jianmin ZHAO
1
;
Ye FENG
1
Author Information
1. 昆山市第二人民医院消化内科，苏州 215300
- Publication Type:Journal Article
- Keywords:
Gastrointestinal stromal tumors;
Gastric fundus;
Nylon rope snare ligation;
Endoscopic full-thickness resection
- From:
Cancer Research and Clinic
2025;37(1):50-54
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To investigate the application effect of nylon rope loop closure in endoscopic full-thickness resection (EFTR) for patients with gastric fundus stromal tumor.Methods:A retrospective cohort study was conducted. A total of 98 patients with gastric fundus stromal tumor admitted to the Second People's Hospital of Kunshan from January 2019 to June 2023 were selected, of which 47 were treated with EFTR (the control group) and 51 were treated with nylon rope closure combined with EFTR (the observation group). The operation related index, nutritional status index, immune index, complications and the recurrence rate of 1-year follow-up were compared between the 2 groups.Results:There were no statistically significant differences in gender, age, tumor diameter, the disease duration and body mass index between the observation group and the control group (all P > 0.05). The operation time [(50±5) min vs. (70±6) min], hospital stay [(6.8±1.0) d vs. (8.6±1.7) d] and anal exhaust time [(1.05±0.21) d vs. (1.39±0.23) d] in the observation group were all shorter than those in the control group; the amount of blood loss in the observation group was lower than that of the control group [(45±5) ml vs. (80±6) ml], and the differences were statistically significant ( t values were 18.28, 6.31, 7.65, 29.28, respectively, all P < 0.05). The levels of nutritional indexes prealbumin, transferrin and albumin in the observation group were higher than those in the control group 3 months after surgery (all P < 0.05); immune indexes CD4 + level and CD4 +/CD8 + in the observation group were lower than those in the control group 3 months after surgery, and the level of CD8 + in the observation group was higher than that in the control group, and the differences were statistically significant (all P < 0.05). In the observation group, 1 case had fever and 1 case had peritonitis, while in the control group, 4 cases had fever, 2 cases had delayed hemorrhage, 2 cases had peritonitis and 1 case had delayed perforation. The incidence of complications in the observation group was lower than that in the control group [3.92% (2/51) vs. 19.15% (9/47)], and the difference was statistically significant ( χ2 = 5.69, P = 0.017). After 1-year follow-up, the recurrence rate in the observation group was lower than that in the control group [1.96% (1/51) vs.12.77% (6/47)], and the difference was statistically significant ( χ2 = 4.31, P = 0.038). Conclusions:Nylon rope loop closure can accelerate the recovery, improve the immune and nutritional status, and reduce the incidence of complications and recurrence of patients with gastric fundus stromal tumor in EFTR.
