Study on the Correlation between the Expression of Plasma TIMP-1,VEGF and LTBP-2 Levels and Risk Stratification and Mortality in Patients with Acute Pulmonary Embolism
10.3969/j.issn.1671-7414.2025.01.032
- VernacularTitle:急性肺栓塞患者血浆TIMP-1,VEGF和LTBP-2水平表达与危险分层及死亡的相关性研究
- Author:
Meisha XU
1
;
Cong WANG
1
;
Youfeng ZHENG
1
;
Tingshi WU
1
;
Chengqin XIAO
1
;
Wei CHEN
1
Author Information
1. 海口市第三人民医院呼吸内科,海口 571100
- Publication Type:Journal Article
- Keywords:
acute pulmonary embolism;
tissue inhibitor of metalloproteinase-1;
vascular endothelial growth factor;
latent transforming growth factor binding protein 2;
risk stratification;
death
- From:
Journal of Modern Laboratory Medicine
2025;40(1):169-173
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between plasma metalloproteinase-tissue inhibitor 1 (TIMP-1),vascular endothelial growth factor (VEGF) and potentially transforming growth factor binding protein 2 (LTBP-2) levels and risk stratification and death in patients with acute pulmonary embolism (APE). Methods A toral of 110 APE patients admitted to the Third People's Hospital of Haikou from January 2022 to January 2024 were selected for risk stratification,and they were divided into low-risk group(n=28),medium-risk group(n=43) and high-risk groups(n=39). According to the occurrence of death in APE patients,they were divided into a survival group (n=79)and a death group(n=31). Enzyme-linked immunosorbent assay (ELISA) was used to measure the levels of plasma TIMP-1,VEGF and LTBP-2. Applying multiple Logistic regression analysis to identify risk factors affecting the mortality of APE patients and plotting ROC curve to analyze the predictive value of plasma TIMP-1,VEGF and LTBP-2 levels for APE patients mortality and. Pearson correlation analysis was used to analyze the correlation between plasma levels of TIMP-1,VEGF and LTBP-2 and clinical indexes in APE patients. Results The heart rate,B-type brain natriuretic peptide (BNP),D-dimer,TIMP-1(207.15±62.84pg/ml vs 152.48±41.62pg/ml),VEGF (726.35±190.46pg/ml vs 419.27±115.28pg/ml) and LTBP-2(29.17±6.38ng/ml vs 13.26±3.70ng/ml) levels in the death group were significantly higher than those in the survival group,the difference were statistically significant (t=5.386～21.194,all P<0.05). The levels of plasma TIMP-1(204.15±60.17 pg/ml,178.18±51.30pg/ml vs 148.20±34.80pg/ml),VEGF(720.83±204.18pg/ml,580.16±158.37pg/ml vs 412.15±109.26pg/ml) and LTBP-2(28.40±6.41ng/ml,21.37±5.26ng/ml vs 12.84±3.12ng/ml) in high-risk and medium-risk groups were significantly higher than those in the low-risk group(t=8.417～19.850),and those in the high-risk group were higher than those in the medium-risk group(t=7.964,9.381,11.470),the differences were statistically significant (all P<0.05),respectively. Multiple Logistic regression analysis showed that increased plasma BNP,D-dimer,TIMP-1,VEGF and LTBP-2 levels were risk factors for death in APE patients (all P<0.05). ROC curve analysis showed that TIMP-1,VEGF and LTBP-2 combined predicted the highest AUC(95％CI) of death in APE patients[0.938(0.881～0.997)],with an accuracy of 88.2％. Pearson correlation analysis showed that the levels of plasma TIMP-1,VEGF and LTBP-2 in APE patients were positively correlated with BNP and D-dimer (r=0.416～0.753,all P<0.05). Conclusion Elevated levels of plasma TIMP-1,VEGF and LTBP-2 are associated with high risk and mortality in APE,and the combination of these three factors has good predictive value for mortality in APE patients.
