Correlation Analysis of Serum PlGF,TREM1 Levels with Clinical Grading and Prognosis in Patients with Diabetes Foot
10.3969/j.issn.1671-7414.2025.01.031
- VernacularTitle:糖尿病足患者血清PlGF,TREM1水平检测与临床分级和预后的相关性分析
- Author:
Jia WANG
1
;
Zhiguo ZHU
;
Fengling QIN
Author Information
1. 桂林医学院附属医院内分泌科,广西桂林541000
- Publication Type:Journal Article
- Keywords:
diabetes foot;
placental growth factor;
triggering receptors expressed on myeloid cells-1
- From:
Journal of Modern Laboratory Medicine
2025;40(1):163-168
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the serum placental growth factor (PlGF) and triggering receptors expressed on myeloid cell-1 (TREM1)levels in patients with diabetes foot,and the correlation between them and clinical grading and prognosis of patients. Methods From January 2021 to January 2023,97 patients with diabetes foot who were admitted to Affiliated Hospital of Guilin Medical University were collected as the study object (diabetes foot group),and 102 healthy people who were examined in the hospital were collected as the healthy control group. The patients with diabetic foot were categorized into 33 cases of grade 0～1,39 cases of grade 2～3,and 25 cases of grade 4～5 according to Wanger grading criteria. Patients with diabetes foot were followed up for 6 months and divided into good prognosis group (n=72) and poor prognosis group (n=25).Serum PlGF and TREM1 levels were compared between groups. Spearman correlation analysis was applied to explore the correlation between serum PlGF and TREM1 levels and clinical grading in patients,factors influencing the prognosis of patients with diabetic foot was analyzed by Logistic regression . Receiver operating characteristic (ROC) curve was applied to investigate the predictive effect of serum PlGF and TREM1 on the prognosis of patients with diabetes foot. Results The expression level of serum PlGF in the diabetes foot group was lower than that in the healthy control group (53.86±15.13 pg/ml vs 87.57±18.28 pg/ml),and the level of TREM1 was significantly higher than that in the healthy control group (279.56±32.25 ng/L vs 195.37±26.28 ng/L),and the difference was statistically significance (t=14.133,20.232,all P<0.05).Serum PlGF expression (39.41±13.28 pg/ml vs 66.13±16.30 pg/ml,52.75±15.32 pg/ml) was lower in patients with clinical grades 4～5 than in patients with grades 0～1 and 2～3. TREM1 expression (326.66±35.75 ng/L vs 248.21±29.83 ng/L,275.89±32.06 ng/L) was higher than in patients with grades 0～1 and 2～3. Serum PlGF expression was lower in patients with clinical grades 2～3 than in patients with grades 0～1. TREM1 expression was higher than in patients with grades 0～1,and the differences were statistically significant (q=5.120～12.945,all P<0.05).Spearman correlation analysis,the serum PlGF expression level in diabetes foot patients was negatively correlated with their clinical grading (r=-0.696,P<0.001) and the TREM1 expression level was positively correlated with their clinical grading (r=0.657,P<0.001).Multivariate Logistic regression anaalysis,PlGF was an independent protective factor[OR(95％CI):0.725(0.531～0.990)]and TREM1 was an independent risk factor[OR(95％CI):2.308(1.284～4.147)]affecting the prognosis of diabetic foot patients.The AUC(95％CI) of PlGF,TREM1 levels and their combination to predict the prognosis of diabetes foot patients was 0.898(0.820～0.950),0.817(0.725～0.888)and 0.949 (0.885～0.984),respectively. The clinical efficacy of the combination of the two in predicting the poor prognosis of patients with diabetes foot was better than that of serum PlGF and TREM1 alone (Z=2.150,2.713,P=0.032,0.007). Conclusion The expression of PlGF in serum of patients with diabetes foot is significantly reduced,and the expression of TREM1 is significantly increased. Both of them are closely related to the clinical grading of patients,and they have good clinical efficacy in predicting prognosis.
