Relationship between serum homocysteine,25-hydroxyvitamin D and frailty and sarcopenia in elderly patients with type 2 diabetes mellitus
10.3969/j.issn.1006-6187.2025.11.005
- VernacularTitle:血清同型半胱氨酸、25羟维生素D及衰弱与老年2型糖尿病合并肌少症相关性的研究
- Author:
Jingrong DAI
1
;
Yan LI
;
Jie LI
;
Hong HUANG
;
Xu HE
;
Fei XIAO
;
Fang HUANG
;
Qingfang LIU
Author Information
1. 410005 长沙,中南大学湘雅医学院附属长沙医院全科医学科
- Publication Type:Journal Article
- Keywords:
Sarcopenia;
Diabetes mellitus,type 2;
Geriatric syndrome;
Homocysteine;
25-hydroxyvitamin D;
Frailty
- From:
Chinese Journal of Diabetes
2025;33(11):820-826
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between serum homocysteine(Hcy),25-hydroxyvitamin D[25(OH)D]and frailty with type 2 diabites mellitus(T2DM)complicated with sarcopenia.Methods From September 2021 to March 2023,210 elderly T2DM patients were selected from the Department of Geriatrics of The First People's Hospital of Yunnan Province,and divided into simple T2DM(n=99)group,mild sarcopenia(M-Sar,n=59)group and severe sarcopenia(S-Sar,n=52)group.The"Elderly Comprehensive Assessment System"was used to evaluate subjects.The influencing factors of T2DM complicated with sarcopenia were analyzed by Logistic regression.The receiver operating characteristic(ROC)curve was used to analyze the predictive value of Hcy,25(OH)D combined with frailty in evaluating T2DM with sarcopenia.Results In T2DM,M-Sar and S-Sar groups,the age,Hcy,the risk rate of balance gait work falling and the rate of weakness increased in turn(P<0.05),while BMI,hemoglobin,25(OH)D,the rate of good nutrition,the normal rate of basic daily living,the low risk rate of falling,the rate of good balance gait function and the rate of no weakness decreased in turn(P<0.05).Logistic regression analysis showed that serum Hcy,frailty and 25(OH)D were the influencing factors of senile T2DM complicated with sarcopenia.Hcy,25(OH)D and frailty combined to predict T2DM with sarcopenia had an area under ROC carve of 0.815,with a sensitivity of 0.811 and a specificity of 0.717.Conclusions Serum Hcy,25(OH)D and frailty are closely related to T2DM combined with sarcopenia.Detection of Hcy and 25(OH)D combined with frailty score is helpful for early diagnosis of sarcopenia in primary hospitals.
