A Prospective Cohort Study on the Association of Maternal Smoking,Alcohol Consumption and Betel Nut Consumption with Risk of Preterm Birth in Offspring
10.11783/j.issn.1002-3674.2025.05.005
- VernacularTitle:母亲吸烟、饮酒和进食槟榔与早产关联的前瞻性队列研究
- Author:
Qi ZOU
1
;
Manjun LUO
;
Xiaorui RUAN
Author Information
1. 中南大学湘雅公共卫生学院流行病与卫生统计学系(410013)
- Publication Type:Journal Article
- Keywords:
Smoking;
Alcohol;
Betel nut;
Preterm birth;
Cohort study
- From:
Chinese Journal of Health Statistics
2025;42(5):666-671
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association of maternal smoking,alcohol consumption and betel nut consumption during pre-pregnancy/early pregnancy with risk of preterm birth in offspring.Methods This first-trimester cohort study was conducted among pregnant women who attended their first prenatal care and were between 8 and 14 gestational weeks in seven maternal and child health hospitals in Hunan Province between August,2014 and December,2019.Information on exposure and preterm birth was collected by using an epidemiological questionnaire combined with the hospital's medical record system.The logistic regression was used to analyze the association of maternal smoking,alcohol consumption,betel nut consumption as well as their interactions and additive effects with risk of preterm birth.Results Among 34104 singleton pregnancies,the incidence of preterm birth was 11.8％(95％CI:11.5％～12.2％).Multivariate logistic regression analyses showed that maternal active smoking(OR=1.246,95％CI:1.016～1.527),passive smoking(OR=1.095,95％CI:1.010～1.187),alcohol consumption(OR=1.619,95％CI:1.372～1.911)and betel nut consumption(OR=1.381,95％CI:1.098～1.737)during pre-pregnancy/early pregnancy were significantly associated with risk of preterm birth.Results from the interaction analysis showed that there were interactions between active smoking and alcohol consumption(OR=0.260,95％CI:0.127～0.530)and between passive smoking and alcohol consumption(OR=1.558,95％CI:1.048～2.322)in the risk of preterm birth.Additive effect analysis showed that the risk of preterm birth increased with the increase of risk behaviors including active smoking,passive smoking,alcohol consumption and betel nut consumption(the range of OR:1.163 to 2.259).Conclusion Maternal active smoking,passive smoking,alcohol consumption,and betel nut consumption during pre-pregnancy/early pregnancy significantly increased the risk of preterm birth.Additionally,women with more of the above risk behaviors had a higher risk of preterm birth,suggesting the importance of keeping healthy behaviors before/during pregnancy to prevent preterm birth.
