Immune checkpoint inhibitor-induced fulminant type 1 diabetes mellitus and severe myocarditis:a case report
10.3969/j.issn.1006-6187.2025.11.012
- VernacularTitle:免疫检查点抑制剂相关爆发1型糖尿病合并重症心肌炎一例报道
- Author:
Jiajia TIAN
1
;
Peng LI
;
Yujuan MA
;
Shentian WANG
Author Information
1. 262500 潍坊市益都中心医院内分泌科
- Publication Type:Journal Article
- Keywords:
Immune checkpoint inhibitors;
Diabetes mellitus,type 1;
Myocarditis
- From:
Chinese Journal of Diabetes
2025;33(11):863-866
- CountryChina
- Language:Chinese
-
Abstract:
Immune checkpoint inhibitors(ICIs)are currently used to treat a variety of tumors.However,there are adverse reactions related to the immune system.Type 1 diabetes mellitus(T1DM)outbreak is a rare endocrine complication,as is ICIs-related myocarditis.This article reports a patient with diabetic ketoacidosis and severe myocarditis after ICIs treatment for lung cancer.After fluid infusion,acid correction,insulin hypoglycemic therapy,and high-dose hormone pulse therapy,the patient showed clinical improvement and was discharged.Through the analysis of the patient's clinical data,we aimed to improve clinicians'understanding of ICIs-associated DM and myocarditis,and to review the literature on possible pathogenesis and treatment.
