Clinical features, diagnosis and treatment of the nasal cavity and skull base inflammatory myofibroblastic tumor
10.3760/cma.j.cn115330-20240911-00519
- VernacularTitle:鼻颅底炎性肌纤维母细胞瘤临床特征及诊治分析
- Author:
Wei ZHONG
1
;
Xuan YUAN
1
;
Lai MENG
1
;
Jiaxin JIA
1
;
Shaobing XIE
1
;
Junyi ZHANG
1
;
Hua ZHANG
1
;
Weihong JIANG
1
;
Zhihai XIE
1
Author Information
1. 中南大学湘雅医院耳鼻咽喉头颈外科 耳鼻咽喉科重大疾病研究湖南省重点实验室 国家老年疾病临床医学研究中心，长沙 410008
- Publication Type:Journal Article
- Keywords:
Skull base;
Inflammatory myofibroblastic tumor;
Paranasal sinuses;
Diagnosis;
Treatment
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2025;60(8):961-966
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To retrospectively analyze the cases of inflammatory myofibroblastic tumor (IMT) involving the sinonasal skull base, and to investigate their clinical characteristics, diagnostic approaches, and treatment outcomes, in order to improve understanding of this rare entity.Methods:Clinical data from five patients with pathologically confirmed sinonasal skull base IMT who underwent surgical treatment at Xiangya Hospital of Central South University between April 2010 and June 2023 were reviewed. Information on clinical presentation, laboratory findings, imaging features, histopathological and immunohistochemical results, treatment strategies, and follow-up outcomes was collected. A comprehensive analysis was performed in combination with a literature review to summarize the clinical features, diagnostic methods, and therapeutic approaches for sinonasal skull base IMT.Results:The five patients (aged 18 to 68 years) were all diagnosed based on histopathological and immunohistochemical examinations. The lesions primarily involved the nasopharynx, clivus, sphenoid sinus, and maxillary sinus. Major clinical symptoms included nasal obstruction, headache, blood-tinged nasal discharge, and facial numbness or pain. All patients underwent surgical resection; two of them also received adjunctive glucocorticoid therapy. During follow-up ranging from 1 to 143 months, two patients experienced tumor recurrence, three patients had no recurrence with significant symptomatic improvement.Conclusions:Histopathology combined with immunohistochemistry is critical for the diagnosis of sinonasal skull base IMT. Complete surgical excision when feasible remains the primary treatment strategy.
