Recent Progress in Biomarkers for the Early Diagnosis of Pulmonary Hypertension
10.3969/j.issn.1671-7414.2025.01.040
- VernacularTitle:肺动脉高压早期诊断的生物标志物最新研究进展
- Author:
Daoxiong WU
1
;
Yanjin LI
;
Yuming WANG
;
Ying HU
;
Ya LIN
;
Run MA
Author Information
1. 昆明医科大学第二附属医院,昆明 650101
- Publication Type:Journal Article
- Keywords:
pulmonary hypertension;
biomarkers;
recent progress
- From:
Journal of Modern Laboratory Medicine
2025;40(1):208-212
- CountryChina
- Language:Chinese
-
Abstract:
Pulmonary hypertension (PH) is a group of progressive diseases characterized by pulmonary vascular remodeling,and some patients already have right heart insufficiency at the time of diagnosis. Therefore,early diagnosis of PH is essential to improve patients' quality of life and prolong survival. Biomarkers are an important indicator for early diagnosis of the disease,and there are many traditional biomarkers for PH diagnosis,but the sensitivity and specificity are low. With the progress of research,some new biomarkers have been shown to predict disease progression in early PH and play an important role in the early diagnosis of PH. This study reviews the research progress of biomarkers of PH from the aspects of right heart insufficiency,endothelial dysfunction,pulmonary artery smooth muscle dysfunction,inflammation,and in situ thrombosis to provide exploration direction and reference value for early diagnosis of PH.
