Comparison of the modified Kadish, AJCC T and Dulguerov T staging systems for olfactory neuroblastoma: analysis of the SEER database
10.3760/cma.j.cn115330-20240723-00438
- VernacularTitle:基于SEER数据库的嗅神经母细胞瘤改良Kadish/AJCC T/Dulguerov T肿瘤分期系统应用比较
- Author:
Huanhuan LYU
1
;
Xin WEN
;
Jingtao LIN
;
Ruihua FANG
;
Rui HE
;
Mengyu CHEN
;
Yihui WEN
;
Weiping WEN
Author Information
1. 中山大学附属第一医院耳鼻咽喉科医院鼻专科 中山大学耳鼻咽喉科研究所 广州市耳鼻咽喉科重点实验室，广州 510080
- Publication Type:Journal Article
- Keywords:
Olfactory neuroblastoma;
SEER Database;
Tumor staging;
Oncologic outcome analysis
- From:
Chinese Journal of Otorhinolaryngology Head and Neck Surgery
2025;60(6):646-653
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To compare the Kadish T staging, AJCC T staging, and Dulguerov T staging system in terms of their impact on surgical treatment selection and survival prognosis in patients with olfactory neuroblastoma (ONB).Methods:The cases of pathologically confirmed ONB from the Surveillance, Epidemiology, and End Results (SEER) database between 2000 and 2018 were collected and screened. Tumors were staged according to Kadish staging system, AJCC T staging and Dulguerov T staging guidelines. Kaplan-Meier analysis was used to calculate 5-and 10-year overall survival rates for different stages, and the log-rank test was used to detect statistically significant differences. Multivariate analysis was performed using Logistic regression and Cox regression models to explore factors influencing surgical treatment choices and prognosis in ONB patients.Results:A total of 519 ONB patients with complete data available for analysis were included in the study. Multivariate analysis revealed that tumor staging, age, and marital status were closely associated with surgical treatment selection. The 10-year survival rates for patients in stage A, B, and C were 74.1%, 68.7%, 55.0%, respectively. The multivariate analysis failed to show a significant prognostic gradient between adjacent stages in any of the three staging systems.Conclusions:The selection of surgical treatment for ONB is influenced by clinical characteristics such as tumor stage and age. The commonly used Kadish, AJCC T, and Dulguerov T staging systems do not significantly differentiate prognosis between adjacent stages, highlighting the need for the development of a more accurate and comprehensive staging system.
