Research progress on hereditary hearing loss associated with LHFPL5 gene
10.3969/j.issn.1006-7299.2025.06.019
- VernacularTitle:LHFPL5基因相关遗传性听力损失研究进展
- Author:
Xuejing BAI
1
;
Dan YE
1
;
Ying ZHU
1
;
Chunting ZHANG
1
;
Wenbo XU
1
Author Information
1. 玉溪市人民医院(玉溪 653100)
- Publication Type:Journal Article
- Keywords:
LH FPL5 gene;
Tetraspan membrane protein;
Transmembrane channel-like 1(TMC1);
Protocadherin-15(PCDH15)
- From:
Journal of Audiology and Speech Pathology
2025;33(6):602-605
- CountryChina
- Language:Chinese
-
Abstract:
LHFPL5 gene is involved in the electromechanical conduction of cochlear hair cells and plays an important role in maintaining hearing and balance functions.This review aims to investigate the mechanism of LHF-PL5 gene and its related proteins in the pathogenesis of hearing loss.We analyzed the hearing loss caused by LHF-PL5 gene mutation,and discussed the characteristics of hearing loss population.The molecular etiology of deafness caused by LHFPL5 gene was discussed through the conclusion and summary of the study results,which provided a basis for whether LHFPL5 gene screening was necessary for deaf people in China,and provided theoretical guidance for subsequent basic research and clinical diagnosis and treatment.
