Advances in experimental models of rheumatoid arthritis
10.3969/j.issn.1005-4847.2025.01.013
- VernacularTitle:类风湿性关节炎实验模型研究进展
- Author:
Junwei WANG
1
;
Xingchao GENG
;
Wei LI
Author Information
1. 中国食品药品检定研究院安全评价研究所,药物非临床安全评价研究北京市重点实验室,北京 100176;中国药科大学多靶标天然药物全国重点实验室,南京 210009
- Publication Type:Journal Article
- Keywords:
rheumatoid arthritis;
animal model;
in vitro model;
inducible model
- From:
Acta Laboratorium Animalis Scientia Sinica
2025;33(1):127-140
- CountryChina
- Language:Chinese
-
Abstract:
Rheumatoid arthritis(RA)is a chronic autoimmune disease that significantly impacts joints.Experimental models are crucial tools for studying the pathogenesis and pharmaco-toxicological mechanisms of RA and screening RA drugs.Commonly used experimental RA models include animal models and in vitro models.With advancements in biotechnology and biomaterials,experimental RA models have evolved from induced and 2D in vitro models to spontaneous gene modification and 3D in vitro models.Moreover,some progress has been made in the study of traditional Chinese medicine disease and syndrome combination models.This paper summarizes the research progress made in the modeling,monitoring,and evaluation of experimental RA models to provide a reference for related research.
